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Details

Stereochemistry ACHIRAL
Molecular Formula C6H10O8
Molecular Weight 210.1388
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GALACTARIC ACID

SMILES

O[C@@H]([C@@H](O)[C@H](O)C(O)=O)[C@@H](O)C(O)=O

InChI

InChIKey=DSLZVSRJTYRBFB-DUHBMQHGSA-N
InChI=1S/C6H10O8/c7-1(3(9)5(11)12)2(8)4(10)6(13)14/h1-4,7-10H,(H,11,12)(H,13,14)/t1-,2+,3+,4-

HIDE SMILES / InChI
Galactaric acid (also known as Mucic acid) is a naturally occurring compound found in fruits, sugar beet and blood. Some basics studies revealed that the acid can be used as a biomarker for diabetic nephropathy diagnosis.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
99mTc-glucarate kinetics differentiate normal, stunned, hibernating, and nonviable myocardium in a perfused rat heart model.
2010-10
The plastid hexokinase pHXK: a node of convergence for sugar and plastid signals in Arabidopsis.
2010-08-20
Small-animal SPECT and SPECT/CT: application in cardiovascular research.
2010-08
Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.
2010-05
Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli.
2010-05
Micellar nanocarriers assembled from doxorubicin-conjugated amphiphilic macromolecules (DOX-AM).
2010-04-08
Identification in Agrobacterium tumefaciens of the D-galacturonic acid dehydrogenase gene.
2010-04
Calcium glucarate inhibits DMBA-induced oral carcinogenesis in the hamster: histomorphometric evaluation.
2010-03
Early hepatic insulin resistance in mice: a metabolomics analysis.
2010-03
Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice.
2010-02
Complete genome sequence and comparative metabolic profiling of the prototypical enteroaggregative Escherichia coli strain 042.
2010-01-20
Molecular mechanisms of hepatic fibrosis in non-alcoholic steatohepatitis.
2010
Toward engineering synthetic microbial metabolism.
2010
De novo design of saccharide-peptide hydrogels as synthetic scaffolds for tailored cell responses.
2009-12-09
Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis .
2009-12-08
Evaluation of patients with head and neck cancer by means of 99mTc-glucarate.
2009-12
Convenient large-scale synthesis of D-glucaro-1,4:6,3-dilactone.
2009-11-06
Significance of urinary glucaric acid measurement and its application to paclitaxel therapy.
2009-11
A major role for perifornical orexin neurons in the control of glucose metabolism in rats.
2009-09
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
2009-09
Synthetic metabolic pipelines.
2009-08
Synthetic protein scaffolds provide modular control over metabolic flux.
2009-08
Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells.
2009-08
Functional states of the genome-scale Escherichia coli transcriptional regulatory system.
2009-06
Molecular imaging of cell death.
2009-06
Seasonal variation of trehalose and glycerol concentrations in winter snow-active insects.
2009-03-13
Comparison of cerebrospinal fluid obtained by ventricular endoscopy and by lumbar puncture in patients with hydrocephalus secondary to neurocysticercosis.
2009-03
In vitro evaluation of the chemoprotective action mechanisms of leontopodic acid against aflatoxin B1 and deoxynivalenol-induced cell damage.
2009-01
Caffeic acid derivatives from Eupatorium perfoliatum L.
2008-12-23
The effect of high glucose on SERT, the human plasmalemmal serotonin transporter.
2008-12
[The biological role of D-glucaric acid and its derivatives: potential use in medicine].
2008-09-05
Clinical applications of urinary organic acids. Part I: Detoxification markers.
2008-09
Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases.
2008-09
Effects of Mirasol PRT treatment on storage lesion development in plasma-stored apheresis-derived platelets compared to untreated and irradiated units.
2008-08
Could 99mTc-glucarate be used to evaluate tumour necrosis? In vitro and in vivo studies in leukaemic tumour cell line U937.
2008-07
Protective effects of D-glucaro-1,4-lactone against oxidative modifications in blood platelets.
2008-07
Relating gene expression data on two-component systems to functional annotations in Escherichia coli.
2008-06-25
The genome of the versatile nitrogen fixer Azorhizobium caulinodans ORS571.
2008-06-04
Genomics of an extreme psychrophile, Psychromonas ingrahamii.
2008-05-06
D-glucaro 1,4-lactone and resveratrol as antioxidants in blood platelets.
2008-04
Evaluating the protective role of ischaemic preconditioning in rat hearts using a stationary small-animal SPECT imager and 99mTc-glucarate.
2008-02
Quorum sensing detected by atomic force microscopy imaging of corrals surrounding multicellular arrangement of bacteria.
2008-02
[Improvement of urinary d-glucaric acid assay and its application].
2008-01
Glycerate kinase of the hyperthermophilic archaeon Thermoproteus tenax: new insights into the phylogenetic distribution and physiological role of members of the three different glycerate kinase classes.
2007-08-31
GntR family of regulators in Mycobacterium smegmatis: a sequence and structure based characterization.
2007-08-23
Evolution of enzymatic activities in the enolase superfamily: L-talarate/galactarate dehydratase from Salmonella typhimurium LT2.
2007-08-21
alpha-ketoglutaric semialdehyde dehydrogenase isozymes involved in metabolic pathways of D-glucarate, D-galactarate, and hydroxy-L-proline. Molecular and metabolic convergent evolution.
2007-03-02
Protective effects of D-glucaro 1,4-lactone against oxidative/nitrative modifications of plasma proteins.
2007-02
Induction of apoptosis by calcium D-glucarate in 7,12-dimethyl benz [a] anthracene-exposed mouse skin.
2007
Esterification of select polyols with D-glucaric acid as model reactions for esterification of starch.
2006-11-27
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
MUCILIANCE
Preferred Name English
GALACTARIC ACID
HSDB   INCI   MI  
INCI  
Official Name English
TETRAHYDROXYADIPIC ACID
Systematic Name English
SACCHAROLACTIC ACID
Common Name English
GALACTARIC ACID [HSDB]
Common Name English
MUCIC ACID
Common Name English
NSC-8127
Code English
GALACTOSACCHARIC ACID
Common Name English
GALACTARIC ACID, (±)-
Common Name English
ORISTAR MCA
Common Name English
GALACTARIC ACID [MI]
Common Name English
Code System Code Type Description
CHEBI
30852
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
WIKIPEDIA
MUCIC ACID
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
FDA UNII
E149J5OTIF
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
PUBCHEM
3037582
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
ECHA (EC/EINECS)
208-404-0
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
MERCK INDEX
m5631
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY Merck Index
CAS
526-99-8
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
CHEBI
17301
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
EPA CompTox
DTXSID7048740
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
NSC
8127
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
MESH
C000090
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY
HSDB
2116
Created by admin on Mon Mar 31 20:50:30 GMT 2025 , Edited by admin on Mon Mar 31 20:50:30 GMT 2025
PRIMARY