Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H15NO3.HI |
| Molecular Weight | 277.1006 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
I.OCCN(CCO)CCO
InChI
InChIKey=AHJXIGQHVVYEGR-UHFFFAOYSA-N
InChI=1S/C6H15NO3.HI/c8-4-1-7(2-5-9)3-6-10;/h8-10H,1-6H2;1H
DescriptionCurator's Comment: Description was created using several sources including:
http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/11340s16lbl.pdf; https://www.ons.org/intervention/trolamine-biafine®; https://www.ncbi.nlm.nih.gov/pubmed/?term=15084618; https://clinicaltrials.gov/ct2/show/NCT02729324; http://www.ncbi.nlm.nih.gov/pubmed/18441842
Curator's Comment: Description was created using several sources including:
http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/11340s16lbl.pdf; https://www.ons.org/intervention/trolamine-biafine®; https://www.ncbi.nlm.nih.gov/pubmed/?term=15084618; https://clinicaltrials.gov/ct2/show/NCT02729324; http://www.ncbi.nlm.nih.gov/pubmed/18441842
Trolamine, an organic compound, is the salt formed between triethanolamine and salicylic acid. It is widely used as a topical analgesic. 10% trolamine salicylate medical products sold over-the-counter such as are creams for temporarily relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, lumbago, neuralgia, strains, bruises, and sprains. The FDA approved in 1958 otic solution drops containing triethanolamine polypeptide used in the ear to break down and loosen earwax was discontinued. Trolamine can enhance skin healing by recruiting macrophages and modifying the concentrations of various immunomodulators. Trolamine (Biafine; Genmedix Ltd, France) is commonly prescribed at the beginning of radiotherapy for preventing acute radiation-induced skin toxicity in China. Biafine has been studied in radiodermatitis and Phase 2 clinical trial has been initiated in 2016 by Sun Yat-sen University to establish the efficacy of trolamine (Biafine) for the management of radiation dermatitis in patients with nasopharyngeal carcinoma receiving IMRT.
Approval Year
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Inactive ingredient | Volu-Firm Approved UseUnknown |
|||
| Palliative | CERUMENEX Approved UseFor removal of impacted cerumen prior to ear examination, otologic therapy and/or audiometry. CERUMENEX Eardrops should be used only with caution in external otitis. Launch Date1958 |
Doses
| Dose | Population | Adverse events |
|---|---|---|
5.38 mg 2 times / day multiple, topical Studied dose Dose: 5.38 mg, 2 times / day Route: topical Route: multiple Dose: 5.38 mg, 2 times / day Sources: |
unhealthy, 21.6–84.9 n = 15 Health Status: unhealthy Condition: Wound Age Group: 21.6–84.9 Sex: M+F Population Size: 15 Sources: |
Disc. AE: Application site erythema... AEs leading to discontinuation/dose reduction: Application site erythema (6.7%) Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Application site erythema | 6.7% Disc. AE |
5.38 mg 2 times / day multiple, topical Studied dose Dose: 5.38 mg, 2 times / day Route: topical Route: multiple Dose: 5.38 mg, 2 times / day Sources: |
unhealthy, 21.6–84.9 n = 15 Health Status: unhealthy Condition: Wound Age Group: 21.6–84.9 Sex: M+F Population Size: 15 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes. | 2003 Apr 2 |
|
| Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. | 2003 Apr 22 |
|
| Enantiomeric separation of TAPP, H-Tyr-(D)Ala-Phe-Phe-NH(2), by capillary electrophoresis using 18-crown-6-tetracarboxylic acid as a chiral selector. | 2003 Aug 15 |
|
| Dynamic localization of SPE-9 in sperm: a protein required for sperm-oocyte interactions in Caenorhabditis elegans. | 2003 Dec 3 |
|
| Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant. | 2003 Feb |
|
| Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope. | 2003 Feb 7 |
|
| Photovoltaic properties of self-assembled monolayers of porphyrins and porphyrin-fullerene dyads on ITO and gold surfaces. | 2003 Jul 30 |
|
| Capillary electrophoresis determinations of trace concentrations of inorganic ions in large excess of chloride: soft modelling using artificial neural networks for optimisation of electrolyte composition. | 2003 Jun |
|
| Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum. | 2003 Mar |
|
| Substantial increase of the ordering temperature for [MnII/MoIII(CN)7]-based magnets as a function of the 3d ion site geometry: example of two supramolecular materials with Tc = 75 and 106 K. | 2003 Mar 10 |
|
| Carbopols as factors buffering triethanolamine interacting with artificial skin sebum. | 2004 |
|
| Effect of some anionic polymers on pH of triethanolamine aqueous solutions. | 2004 |
|
| Determination of alkanolamines in cattails (Typha latifolia) utilizing electrospray ionization with selected reaction monitoring and ion-exchange chromatography. | 2004 |
|
| Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. | 2004 Apr 15 |
|
| Synthesis, structure and magnetism of new single molecule magnets composed of MnII2MnIII2 alkoxo-carboxylate bridged clusters capped by triethanolamine ligands. | 2004 Apr 7 |
|
| [The problem and improvement of colorimetric method for determination of sulfite in foods containing sulfur compounds]. | 2004 Dec |
|
| Complete charge pooling is prevented in viologen-based dendrimers by self-protection. | 2004 Dec 3 |
|
| Analysis of Tamm-Horsfall protein by high-performance liquid chromatography with native fluorescence. | 2004 Feb 20 |
|
| On-line collection/concentration and detection of sulfur dioxide in air by flow-injection spectrophotometry coupled with a chromatomembrane cell. | 2004 Jan |
|
| Evaluation of method of preparation of passive diffusion tubes for measurement of ambient nitrogen dioxide. | 2004 Jan |
|
| Mechanical and water barrier properties of glutenin films influenced by storage time. | 2004 Jan 14 |
|
| Rheological characterization of topical carbomer gels neutralized to different pH. | 2004 Jul |
|
| Lactic acid production with lactate dehydrogenase using the visible light sensitization of zinc porphyrin. | 2004 Jul |
|
| Triethanolamine zinc phosphite, (C6H13NO3)Zn2(HPO3): a templated network or a network of clusters? | 2004 Jul 26 |
|
| Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population. | 2004 Jul-Aug |
|
| Integrative analysis of the mitochondrial proteome in yeast. | 2004 Jun |
|
| Evaluation of the potential of triethanolamine to alter hepatic choline levels in female B6C3F1 mice. | 2004 Jun |
|
| Alternative approach to enhancing cation selectivity in ion chromatography. | 2004 Jun 11 |
|
| Cubic phase prepared in an anionic/amphoteric surfactant/oleic acid/decane/water system and the relationship with the neighboring phase. | 2004 Mar 30 |
|
| [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. | 2004 May |
|
| NTP toxicology and carcinogenesis studies of triethanolamine (Cas No. 102-71-6) in B6C3F1 mice (dermal studies). | 2004 May |
|
| Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol. | 2004 May 4 |
|
| Titanatranes derailed: static and dynamic triethanolamine slippage induced by polyphenoxide chelation. | 2004 Nov 1 |
|
| A high-nuclearity "Celtic-ring" isopolyoxotungstate, [H12W36O120]12-, that captures trace potassium ions. | 2004 Nov 3 |
|
| Efficient photocurrent generation by self-assembled monolayers composed of 3 10-helical peptides carrying linearly spaced naphthyl groups at the side chains. | 2004 Oct 13 |
|
| Determination of volatile corrosion inhibitors by capillary electrophoresis. | 2004 Oct 8 |
|
| Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG). | 2004 Sep |
|
| Determination of diethanolamine or N-methyldiethanolamine in high ammonium concentration matrices by capillary electrophoresis with indirect UV detection: application to the analysis of refinery process waters. | 2004 Sep |
|
| Functionalized metal oxide clusters: synthesis, characterization, crystal structures, and magnetic properties of a novel series of fully reduced heteropolyoxovanadium cationic clusters decorated with organic ligands--[MVIV6O6[(OCH2CH2)2N(CH2CH2OH)]6]X (M = Li, X = Cl x LiCl; M = Na, X = Cl x H2O; M = Mg, X = 2Br x H2O; M = Mn, Fe, X = 2Cl; M = Co, Ni, X = 2Cl x H2O). | 2004 Sep 20 |
|
| Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces. | 2004 Sep 28 |
|
| Photosensitized hydrogen evolution from water using conjugated polymers wrapped in dendrimeric electrolytes. | 2004 Sep 29 |
|
| Co phytoavailability for tomato in amended calcareous soils. | 2005 Apr |
|
| Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography. | 2005 Feb 14 |
|
| Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes. | 2005 Jan 21 |
|
| Generation of human antibody fragments against Streptococcus mutans using a phage display chain shuffling approach. | 2005 Jan 25 |
|
| New structural motifs in manganese single-molecule magnetism from the use of triethanolamine ligands. | 2005 Jan 28 |
|
| Ion chromatographic analysis of amines, alkanolamines, and associated anions in concrete. | 2005 Mar |
|
| A factor analysis for complex systems containing nimesulide. | 2005 Mar |
|
| Photoreduction behavior of cytochrome c by zinc porphyrin in lipid media. | 2005 May 13 |
|
| Effect of cationic micellar aggregates on the kinetics of oxidation of aminoalcohols by N-bromosuccinimide in alkaline medium. | 2005 May 15 |
Sample Use Guides
Fill ear canal with ear drops of 10% triethanolamine Polypeptide Oleate-Condensate with the patient’s head tilted at a 45° angle. Insert cotton plug and allow to remain 15-30 minutes. Then gently flush with lukewarm water, using a soft rubber syringe (avoid excessive pressure). Exposure of skin outside the ear to the drug should be avoided. The procedure may be repeated if the first application fails to clear the impaction.
Route of Administration:
Otic (auricular)
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
2723762
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
1942478
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
DT98IT03JK
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
231-508-2
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
100000077294
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
7601-53-8
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
SUB15611MIG
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
DT98IT03JK
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY | |||
|
DTXSID60226921
Created by
admin on Fri Dec 15 19:42:54 GMT 2023 , Edited by admin on Fri Dec 15 19:42:54 GMT 2023
|
PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
