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Details

Stereochemistry ACHIRAL
Molecular Formula C6H15NO3.HI
Molecular Weight 277.1006
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIETHANOLAMINE HYDRIODIDE

SMILES

I.OCCN(CCO)CCO

InChI

InChIKey=AHJXIGQHVVYEGR-UHFFFAOYSA-N
InChI=1S/C6H15NO3.HI/c8-4-1-7(2-5-9)3-6-10;/h8-10H,1-6H2;1H

HIDE SMILES / InChI

Molecular Formula HI
Molecular Weight 127.91241
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C6H15NO3
Molecular Weight 149.1882
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created using several sources including: http://www.accessdata.fda.gov/drugsatfda_docs/label/2002/11340s16lbl.pdf; https://www.ons.org/intervention/trolamine-biafine®; https://www.ncbi.nlm.nih.gov/pubmed/?term=15084618; https://clinicaltrials.gov/ct2/show/NCT02729324; http://www.ncbi.nlm.nih.gov/pubmed/18441842

Trolamine, an organic compound, is the salt formed between triethanolamine and salicylic acid. It is widely used as a topical analgesic. 10% trolamine salicylate medical products sold over-the-counter such as are creams for temporarily relief of minor aches and pains of muscles and joints associated with arthritis, simple backache, lumbago, neuralgia, strains, bruises, and sprains. The FDA approved in 1958 otic solution drops containing triethanolamine polypeptide used in the ear to break down and loosen earwax was discontinued. Trolamine can enhance skin healing by recruiting macrophages and modifying the concentrations of various immunomodulators. Trolamine (Biafine; Genmedix Ltd, France) is commonly prescribed at the beginning of radiotherapy for preventing acute radiation-induced skin toxicity in China. Biafine has been studied in radiodermatitis and Phase 2 clinical trial has been initiated in 2016 by Sun Yat-sen University to establish the efficacy of trolamine (Biafine) for the management of radiation dermatitis in patients with nasopharyngeal carcinoma receiving IMRT.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Inactive ingredient
Volu-Firm

Approved Use

Unknown
Palliative
CERUMENEX

Approved Use

For removal of impacted cerumen prior to ear examination, otologic therapy and/or audiometry. CERUMENEX Eardrops should be used only with caution in external otitis.

Launch Date

1958
Doses

Doses

DosePopulationAdverse events​
5.38 mg 2 times / day multiple, topical
Studied dose
Dose: 5.38 mg, 2 times / day
Route: topical
Route: multiple
Dose: 5.38 mg, 2 times / day
Sources:
unhealthy, 21.6–84.9
Disc. AE: Application site erythema...
AEs leading to
discontinuation/dose reduction:
Application site erythema (6.7%)
Sources:
AEs

AEs

AESignificanceDosePopulation
Application site erythema 6.7%
Disc. AE
5.38 mg 2 times / day multiple, topical
Studied dose
Dose: 5.38 mg, 2 times / day
Route: topical
Route: multiple
Dose: 5.38 mg, 2 times / day
Sources:
unhealthy, 21.6–84.9
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Preliminary assessment of selected methacrylic acid--acrylic acid copolymers as factors buffering triethanolamine interacting with artificial skin sebum.
2001
[Enantiomeric separation of drugs with capillary electrophoresis with cyclodextrins].
2001
Comparative studies of various run buffers for chiral capillary electrophoresis using chiral crown ether as a chiral selector.
2001 Dec
Bis(triethanolamine)cadmium(II) and -mercury(II) saccharinates: seven-coordinate complexes containing both tri- and tetradentate triethanolamine ligands.
2001 Dec
Extraction and separation of cationic surfactants from river sediments: application to a spectrophotometric determination of cationic surfactant in an aquatic environment using membrane filters.
2001 Nov
Application of membrane filters for spectrophotometric determination of cationic surfactants in river water and sediment.
2001 Nov-Dec
[Determination of sulfite residues in foods by using the modified rankine apparatus and HPLC].
2001 Oct
Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin.
2002 Apr 2
Analysis of illicit amphetamine seizures by capillary zone electrophoresis.
2002 Dec 6
Synthesis and characterization of mesoporous indium tin oxide possessing an electronically conductive framework.
2002 Jul 24
Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures.
2002 Jun
Performances and application of a passive sampling method for the simultaneous determination of nitrogen dioxide and sulfur dioxide in ambient air.
2002 Nov
The enhancing effect of a triethanolamine-ethanol-isopropyl myristate mixed system on the skin permeation of acidic drugs.
2002 Oct
Sustaining pattern of phenformin hydrochloride using various polymers and waxes.
2002 Sep-Oct
Carcinostatic, protective, and adaptive activities of tris-(2-hydroxyethyl)ammonium salts of arylheteroacetic acids.
2002 Sep-Oct
Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes.
2003 Apr 2
The use of complexation with alkanolamines to facilitate skin permeation of mefenamic acid.
2003 Aug 27
A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro.
2003 Dec 1
Expression and function of bradykinin receptors in microglia.
2003 Feb 21
Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope.
2003 Feb 7
Photovoltaic properties of self-assembled monolayers of porphyrins and porphyrin-fullerene dyads on ITO and gold surfaces.
2003 Jul 30
Preliminary assessment of alginic acid as a factor buffering triethanolamine interacting with artificial skin sebum.
2003 Mar
Synthesis of uniform anatase TiO2 nanoparticles by gel-sol method. 3. Formation process and size control.
2003 Mar 1
Substantial increase of the ordering temperature for [MnII/MoIII(CN)7]-based magnets as a function of the 3d ion site geometry: example of two supramolecular materials with Tc = 75 and 106 K.
2003 Mar 10
Modification and validation of the pyromellitic acid electrolyte for the capillary electrophoretic determination of anions.
2003 May 2
Reactivity with Tris(hydroxymethyl)aminomethane confounds immunodetection of acrolein-adducted proteins.
2003 Oct
Identification of selenium species in urine by ion-pairing HPLC-ICP-MS using laboratory-synthesized standards.
2003 Oct
Extracting material parameters from x-ray attenuation: a CT feasibility study using kilovoltage synchrotron x-rays incident upon low atomic number absorbers.
2003 Oct 21
Direct and fast capillary zone electrophoretic method for the determination of Gleevec and its main metabolite in human urine.
2003 Sep 5
Carbopols as factors buffering triethanolamine interacting with artificial skin sebum.
2004
Effect of some anionic polymers on pH of triethanolamine aqueous solutions.
2004
Determination of alkanolamines in cattails (Typha latifolia) utilizing electrospray ionization with selected reaction monitoring and ion-exchange chromatography.
2004
Analysis of Tamm-Horsfall protein by high-performance liquid chromatography with native fluorescence.
2004 Feb 20
Mixture additives inhibit the dermal permeation of the fatty acid, ricinoleic acid.
2004 Feb 28
On-line collection/concentration and detection of sulfur dioxide in air by flow-injection spectrophotometry coupled with a chromatomembrane cell.
2004 Jan
Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines.
2004 Jan
Mechanical and water barrier properties of glutenin films influenced by storage time.
2004 Jan 14
Rheological characterization of topical carbomer gels neutralized to different pH.
2004 Jul
Lactic acid production with lactate dehydrogenase using the visible light sensitization of zinc porphyrin.
2004 Jul
Integrative analysis of the mitochondrial proteome in yeast.
2004 Jun
Cubic phase prepared in an anionic/amphoteric surfactant/oleic acid/decane/water system and the relationship with the neighboring phase.
2004 Mar 30
NTP toxicology and carcinogenesis studies of triethanolamine (Cas No. 102-71-6) in B6C3F1 mice (dermal studies).
2004 May
Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG).
2004 Sep
Determination of diethanolamine or N-methyldiethanolamine in high ammonium concentration matrices by capillary electrophoresis with indirect UV detection: application to the analysis of refinery process waters.
2004 Sep
Functionalized metal oxide clusters: synthesis, characterization, crystal structures, and magnetic properties of a novel series of fully reduced heteropolyoxovanadium cationic clusters decorated with organic ligands--[MVIV6O6[(OCH2CH2)2N(CH2CH2OH)]6]X (M = Li, X = Cl x LiCl; M = Na, X = Cl x H2O; M = Mg, X = 2Br x H2O; M = Mn, Fe, X = 2Cl; M = Co, Ni, X = 2Cl x H2O).
2004 Sep 20
Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces.
2004 Sep 28
New structural motifs in manganese single-molecule magnetism from the use of triethanolamine ligands.
2005 Jan 28
Ion chromatographic analysis of amines, alkanolamines, and associated anions in concrete.
2005 Mar
Photoreduction behavior of cytochrome c by zinc porphyrin in lipid media.
2005 May 13
Effect of cationic micellar aggregates on the kinetics of oxidation of aminoalcohols by N-bromosuccinimide in alkaline medium.
2005 May 15
Patents

Sample Use Guides

Fill ear canal with ear drops of 10% triethanolamine Polypeptide Oleate-Condensate with the patient’s head tilted at a 45° angle. Insert cotton plug and allow to remain 15-30 minutes. Then gently flush with lukewarm water, using a soft rubber syringe (avoid excessive pressure). Exposure of skin outside the ear to the drug should be avoided. The procedure may be repeated if the first application fails to clear the impaction.
Route of Administration: Otic (auricular)
Penetration of triethanolamine into artificial skin sebum and its uplift were measured using 0.1 M aqueous triethanolamine solution.
Substance Class Chemical
Created
by admin
on Mon Mar 31 19:54:34 GMT 2025
Edited
by admin
on Mon Mar 31 19:54:34 GMT 2025
Record UNII
DT98IT03JK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRIETHANOLAMINE HYDRIODIDE
Systematic Name English
TEA-HYDROIODIDE
INCI  
INCI  
Preferred Name English
IODOTRAT
Brand Name English
Triethanolammonium iodide [WHO-DD]
Common Name English
IODERMOL
Brand Name English
ETHANOL, 2,2',2''-NITRILOTRIS-, HYDRIODIDE (1:1)
Common Name English
TRIETHANOLAMMONIUM IODIDE
WHO-DD  
Common Name English
ETHANOL, 2,2',2''-NITRILOTRIS-, HYDRIODIDE
Common Name English
ETHANOL, 2,2',2''-NITRILOTRI-, HYDRIODIDE
Common Name English
Code System Code Type Description
PUBCHEM
2723762
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
RXCUI
1942478
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
FDA UNII
DT98IT03JK
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
ECHA (EC/EINECS)
231-508-2
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
SMS_ID
100000077294
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
CAS
7601-53-8
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
EVMPD
SUB15611MIG
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
DAILYMED
DT98IT03JK
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
EPA CompTox
DTXSID60226921
Created by admin on Mon Mar 31 19:54:34 GMT 2025 , Edited by admin on Mon Mar 31 19:54:34 GMT 2025
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE