MESUDIPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H24N2O4S
Molecular Weight	376.47
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CN=C2SC)C(=O)OCC

InChI

InChIKey=DYGIPCPWPHKLMC-UHFFFAOYSA-N

InChI=1S/C19H24N2O4S/c1-6-24-18(22)14-11(3)21-12(4)15(19(23)25-7-2)16(14)13-9-8-10-20-17(13)26-5/h8-10,16,21H,6-7H2,1-5H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3720845 | https://www.ncbi.nlm.nih.gov/pubmed/3708217 | https://www.ncbi.nlm.nih.gov/pubmed/6852110 | https://www.ncbi.nlm.nih.gov/pubmed/6601967

Mesudipine, a dihydropyridine analog, is a calcium antagonistic drug (slow channel blocker). It blocks electrical activity in smooth muscle cells and Purkinje fibers.

Approval Year

PubMed

Title	Date	PubMed
Depression of contractions of rabbit aorta and guinea pig vena cava by mesudipine and other slow channel blockers.	1983	6601967
Comparison of the effects of several calcium antagonistic drugs on the electrical activity of guinea pig Purkinje fibers.	1983 Mar 25	6852110
Effects of calcium antagonistic drugs on the electrical activity of rabbit sino-atrial node.	1986 May	3708217
New dihydropyridine drug, nilvadipine, blocks the calcium slow action potential in rat-cultured aortic smooth muscle cells.	1986 May 13	3720845

Sample Use Guides

In Vitro Use Guide

Mesudipine at 10 nM and 40 nM depressed the Vmax, amplitude and duration of the slow action potentials of guinea pig Purkinje fibers and abolished excitability within 11 min at 100 nM. At 100 nM, mesudipine blocked the slow action potentials earlier (within 3 min) at higher stimulation frequency (from the usual drive rate of 0.5-1.5 Hz).

Name

Type

Language

MESUDIPINE

Official Name

English

DIETHYL 1',4'-DIHYDRO-2',6'-DIMETHYL-2-(METHYLTHIO)(3,4'-BIPYRIDINE)-3',5'-DICARBOXYLATE

Systematic Name

English

mesudipine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333