Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C39H48N4O4 |
| Molecular Weight | 636.8228 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCOC(C)C1=C2NC(C=C3N=C([C@@H](CCC(O)=O)[C@@H]3C)C4=C5NC(=CC6=NC(=C2)C(C)=C6CC)C(C)=C5C(=O)C4)=C1C
InChI
InChIKey=PVXGCBZIVFCMJK-NMWXTPPCSA-N
InChI=1S/C39H48N4O4/c1-8-10-11-12-15-47-24(7)36-22(5)30-17-29-21(4)26(13-14-35(45)46)38(42-29)27-16-34(44)37-23(6)31(43-39(27)37)18-32-25(9-2)20(3)28(40-32)19-33(36)41-30/h17-19,21,24,26,41,43H,8-16H2,1-7H3,(H,45,46)/b28-19-,29-17-,30-17-,31-18-,32-18-,33-19-,38-27-/t21-,24?,26-/m0/s1
2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH), a chlorin-based photosensitize, is used in photodynamic therapy. It has been shown the therapeutic potential of HPPH in phase II clinical trials for the treatment of esophageal cancer. Besides, HPPH participated in clinical trials in treating patients with advanced non-small cell lung cancer that blocks the air passages. However, these studies were terminated.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. | 1994 Sep-Oct |
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| Stereoselective determination of p-hydroxyphenyl-phenylhydantoin enantiomers in rat liver microsomal incubates by reversed-phase high-performance liquid chromatography using beta-cyclodextrin as chiral mobile phase additives. | 2001 Apr |
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| Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors. | 2001 Apr |
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| Effect of mild therapeutic hypothermia on phenytoin pharmacokinetics. | 2001 Jun |
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| Effects of cysteine on the pharmacokinetics of intravenous phenytoin in rats with protein-calorie malnutrition. | 2001 Oct 23 |
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| Analytic performance evaluation of a new turbidimetric immunoassay for phenytoin on the ADVIA 1650 analyzer: effect of phenytoin metabolite and analogue. | 2005 Jun |
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| Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients. | 2006 Sep |
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| High-performance liquid chromatographic method for determination of phenytoin in rabbits receiving sildenafil. | 2008 Apr 18 |
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| Phenytoin metabolite renal calculus: an index case. | 2008 Aug |
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| CYP2C9 amino acid residues influencing phenytoin turnover and metabolite regio- and stereochemistry. | 2009 Jun |
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| Determination of phenytoin and its major metabolite in human serum by MEKC. | 2009 Nov-Dec |
|
| Suppression of LPS-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin. | 2010 Sep 15 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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FDA ORPHAN DRUG |
640418
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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NCI_THESAURUS |
C1420
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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149402-51-7
Created by
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PRIMARY | |||
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DTXSID501028872
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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PRIMARY | |||
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DOB7Y3RSX0
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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PRIMARY | |||
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DB15243
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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PRIMARY | |||
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2-(1-Hexyloxyethyl)-2-devinyl pyropheophorbide-a
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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PRIMARY | |||
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C2636
Created by
admin on Fri Dec 15 15:55:07 UTC 2023 , Edited by admin on Fri Dec 15 15:55:07 UTC 2023
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PRIMARY |
SUBSTANCE RECORD
