Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C11H12N2S.ClH |
Molecular Weight | 240.752 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.C1CN2C[C@@H](N=C2S1)C3=CC=CC=C3
InChI
InChIKey=LAZPBGZRMVRFKY-HNCPQSOCSA-N
InChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
Levamisole (the trade name Ergamisol), an anthelminthic drug with immunological properties. It also has antitumor activity when administered with 5-fluorouracil in patients with Duke's C colorectal carcinoma; however, this use was discontinued. The mechanism of the antitumor effect is unknown but has been postulated to be related to levamisole's immunomodulatory properties. Levamisole can stimulate antibody formation to various antigens, enhance T-cell responses by stimulating T-cell activation and proliferation, potentiate monocyte and macrophage functions including phagocytosis, chemotaxis and increases motility, adherence, and chemotaxis. Levamisole inhibits alkaline phosphatase and possesses cholinergic activity. The mechanism of action of levamisole as an antiparasitic agent, for example, to treat ascariasis, relates to its agonistic activity to L-subtype nicotinic acetylcholine receptors in nematode muscles. In addition, levamisole was studied for preventing relapses of the steroid-sensitive idiopathic nephrotic syndrome (SSINS). It was shown, that alone or in combination with steroids, the drug can prolong the time to relapse and prevented recurrence during one year of treatment. However, these studies also were also discontinued.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P05186|||Q5BKZ5 Gene ID: 249.0 Gene Symbol: ALPL Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/28209522 |
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Target ID: CHEMBL1884 Sources: https://www.ncbi.nlm.nih.gov/pubmed/19668355 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | ERGAMISOL Approved UseUnknown Launch Date6.4558078E11 |
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Curative | Unknown Approved UseUnknown |
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Preventing | Unknown Approved UseUnknown |
Cmax
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
0.76 mg/L |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
1.93 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
1.53 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
1.84 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
0.72 mg/L |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
0.75 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
0.74 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
1.28 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
0.97 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
0.69 mg/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
0.53 mg/L |
2.5 mg/kg bw 1 times / 2 days multiple, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: UNKNOWN food status: UNKNOWN |
AUC
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
4.15 mg × h/L |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
13.78 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
18.96 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
19.69 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
3.07 mg × h/L |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
4.48 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
6.1 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
6.88 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
7.16 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
7.44 mg × h/L EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
3.54 mg × h/L |
2.5 mg/kg bw 1 times / 2 days multiple, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: UNKNOWN food status: UNKNOWN |
T1/2
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
4.4 h |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
3.65 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
5.75 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
5.58 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
5.56 h |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
2.85 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: FASTED |
|
3.88 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
2.71 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
5 mg/kg bw single, oral dose: 5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
3.72 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE food status: FASTED |
|
6.04 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/7166176/ |
2.5 mg/kg bw single, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED |
|
3.07 h |
2.5 mg/kg bw 1 times / 2 days multiple, oral dose: 2.5 mg/kg bw route of administration: Oral experiment type: MULTIPLE co-administered: |
LEVAMISOLE plasma | Homo sapiens population: UNHEALTHY age: CHILD sex: UNKNOWN food status: UNKNOWN |
Funbound
Value | Dose | Co-administered | Analyte | Population |
---|---|---|---|---|
49% |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
49% |
150 mg unknown, oral dose: 150 mg route of administration: Oral experiment type: UNKNOWN co-administered: |
LEVAMISOLE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
Doses
Dose | Population | Adverse events |
---|---|---|
50 mg 2 times / day multiple, oral Dose: 50 mg, 2 times / day Route: oral Route: multiple Dose: 50 mg, 2 times / day Sources: |
unhealthy, 15 years n = 1 Health Status: unhealthy Age Group: 15 years Sex: M Population Size: 1 Sources: |
Disc. AE: Epidermal necrolysis... AEs leading to discontinuation/dose reduction: Epidermal necrolysis (1 patient) Sources: |
100 mg 1 times / day multiple, oral Dose: 100 mg, 1 times / day Route: oral Route: multiple Dose: 100 mg, 1 times / day Sources: |
unhealthy, 34 years n = 1 Health Status: unhealthy Age Group: 34 years Sex: F Population Size: 1 Sources: |
Disc. AE: Myopathy, Leukocytoclastic vasculitis... AEs leading to discontinuation/dose reduction: Myopathy (1 patient) Sources: Leukocytoclastic vasculitis (1 patient) |
250 mg single, intravenous Overdose Dose: 250 mg Route: intravenous Route: single Dose: 250 mg Sources: |
unknown, 52 years n = 1 Health Status: unknown Age Group: 52 years Sex: M Population Size: 1 Sources: |
Other AEs: Adverse event... |
3.5 mg/kg 1 times / day multiple, oral Highest studied dose Dose: 3.5 mg/kg, 1 times / day Route: oral Route: multiple Dose: 3.5 mg/kg, 1 times / day Sources: |
unhealthy, 7-12 years n = 28 Health Status: unhealthy Condition: pediculosis capitis Age Group: 7-12 years Sex: F Population Size: 28 Sources: |
|
150 mg 1 times / week multiple, oral Dose: 150 mg, 1 times / week Route: oral Route: multiple Dose: 150 mg, 1 times / week Sources: |
unhealthy Health Status: unhealthy Sources: |
Disc. AE: Agranulocytosis... AEs leading to discontinuation/dose reduction: Agranulocytosis Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Epidermal necrolysis | 1 patient Disc. AE |
50 mg 2 times / day multiple, oral Dose: 50 mg, 2 times / day Route: oral Route: multiple Dose: 50 mg, 2 times / day Sources: |
unhealthy, 15 years n = 1 Health Status: unhealthy Age Group: 15 years Sex: M Population Size: 1 Sources: |
Leukocytoclastic vasculitis | 1 patient Disc. AE |
100 mg 1 times / day multiple, oral Dose: 100 mg, 1 times / day Route: oral Route: multiple Dose: 100 mg, 1 times / day Sources: |
unhealthy, 34 years n = 1 Health Status: unhealthy Age Group: 34 years Sex: F Population Size: 1 Sources: |
Myopathy | 1 patient Disc. AE |
100 mg 1 times / day multiple, oral Dose: 100 mg, 1 times / day Route: oral Route: multiple Dose: 100 mg, 1 times / day Sources: |
unhealthy, 34 years n = 1 Health Status: unhealthy Age Group: 34 years Sex: F Population Size: 1 Sources: |
Adverse event | grade 5 | 250 mg single, intravenous Overdose Dose: 250 mg Route: intravenous Route: single Dose: 250 mg Sources: |
unknown, 52 years n = 1 Health Status: unknown Age Group: 52 years Sex: M Population Size: 1 Sources: |
Agranulocytosis | Disc. AE | 150 mg 1 times / week multiple, oral Dose: 150 mg, 1 times / week Route: oral Route: multiple Dose: 150 mg, 1 times / week Sources: |
unhealthy Health Status: unhealthy Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Chronic HBV infection. Immunomodulation with levamisole in viremic HBeAg positive or anti-HBe positive patients--a pilot study. | 1999 Nov-Dec |
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Disseminated autoimmune disease during levamisole treatment of nephrotic syndrome. | 1999 Sep |
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Multifocal demyelinative leukoencephalopathy associated with 5-fluorouracil and levamisole. | 2000 |
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Tumour necrosis factor-alpha production in fibrosing alveolitis is macrophage subset specific. | 2001 |
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Non-corticosteroid treatment for nephrotic syndrome in children. | 2001 |
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Optimising the benefits of anthelmintic treatment in children. | 2001 |
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Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells. | 2001 |
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Levamisole induced ataxia. | 2001 Apr |
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Genes affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior. | 2001 Apr |
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Leukoencephalopathy following chemotherapy for colonic carcinoma. | 2001 Apr |
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Indirect atomic absorption determination of atropine, diphenhydramine, tolazoline, and levamisole based on formation of ion-associates with potassium tetraiodometrcurate. | 2001 Apr |
|
Molecular predictors of survival after adjuvant chemotherapy for colon cancer. | 2001 Apr 19 |
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Amplified fragment length polymorphism analysis of genetic diversity of Haemonchus contortus during selection for drug resistance. | 2001 Aug |
|
Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating. | 2001 Dec 14 |
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Fourth International Conference on Colorectal Cancer: adjuvant treatment of colon cancer--introduction. | 2001 Feb |
|
Partial purification and biochemical characterization of a heteromeric protein phosphatase 2A holoenzyme from maize (Zea mays L.) leaves that dephosphorylates C4 phosophoenolpyruvate carboxylase. | 2001 Jul |
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Transmission studies on Trichinella species isolated from Crocodylus niloticus and efficacy of fenbendazole and levamisole against muscle L1 stages in Balb C mice. | 2001 Mar |
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Comparison of 5-fluorouracil alone, 5-fluorouracil with levamisole, and 5-fluorouracil with hepatic irradiation in the treatment of patients with residual, nonmeasurable, intra-abdominal metastasis after undergoing resection for colorectal carcinoma. | 2001 Mar 1 |
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Fluorouracil plus leucovorin as effective adjuvant chemotherapy in curatively resected stage III colon cancer: results of the trial adjCCA-01. | 2001 Mar 15 |
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Immunosuppressive agents in childhood nephrotic syndrome: a meta-analysis of randomized controlled trials. | 2001 May |
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Levamisole vs. cyclophosphamide for frequently-relapsing steroid-dependent nephrotic syndrome. | 2001 Oct |
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A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. | 2001 Oct 11 |
|
Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity. | 2002 |
|
Role of a novel soluble nucleotide phospho-hydrolase from sheep plasma in inhibition of platelet reactivity: hemostasis, thrombosis, and vascular biology. | 2002 Feb |
|
Characterization and cytochemical localization of an ATP diphosphohydrolase from Leishmania amazonensis promastigotes. | 2002 Feb |
|
The effect of dietary immunomodulation upon Edwardsiella tarda vaccination in healthy and immunocompromised Indian major carp (Labeo rohita). | 2002 Jan |
|
Canine serum alkaline phosphatase isoenzymes detected by polyacrylamide gel disk electrophoresis. | 2002 Jan |
|
Unique Ca(2+)-activated ATPase in the nervous ganglia of Phyllocaulis soleiformis (Mollusca). | 2002 Jan |
|
Superantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells. | 2002 Mar 4 |
Sample Use Guides
In Vivo Use Guide
Sources: http://home.intekom.com/pharm/janssen/ergamis.html
The combination of ERGAMISOL (levamisole hydrochloride) and 5-fluorouracil is administered according to the following dosage schedule:
Initial Therapy: Week 1 (3rd to 4th week post surgery): 5-fluorouracil 450 mg/m² i.v. push days 1 –5 and ERGAMISOL 50 mg orally t.i.d days 1 –3; Week 3 only ERGAMISOL 50 mg orally t.i.d days 1 –3. Therapy should commence 3 –4 weeks post surgery.
5-Fluorouracil (450 mg/m²) is administered by rapid i.v. injection for the first 5 days of Week 1.
ERGAMISOL 50 mg tablet is administered orally three times a day for the first 3 days of Week 1, and again on the first 3 days of Week 3.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1790137
It was examined the immunological effects of levamisole in vitro. Experiments utilized peripheral blood mononuclear cells from normal donors incubated in the presence of increasing concentrations of levamisole (0.1 to 100 micrograms/ml). Levamisole had no consistent effect on induction of 2',5'-oligoadenylate synthetase activity or indoleamine-2,3-dioxygenase activity, or production of tumor necrosis factor. Levamisole had no effect on monocyte cytotoxicity or expression of HLA-DR, HLA-DQ, HLA-DP, and the Fc receptor. Similarly, levamisole had no significant effect on NK or LAK cytotoxicity or the immunological activation of T-lymphocytes, assessed by expression of CD3, CD4, CD8, CD16, CD25, and CD56. No significant enhancement in the expression of three tumor-associated antigens (880364, NRCO-4, and ING-1) and the intercellular adhesion molecule-1 (ICAM-1) antigen on four human cancer cell lines was observed following in vitro exposure to levamisole. In conclusion, was revealed, that levamisole was not a potent modulator of the immune parameters.
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Classification Tree | Code System | Code | ||
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EU-Orphan Drug |
EU/3/05/324
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CFR |
21 CFR 520.1242E
Created by
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NCI_THESAURUS |
C2141
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CFR |
21 CFR 556.350
Created by
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Code System | Code | Type | Description | ||
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16595-80-5
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DBSALT000822
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C610
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LEVAMISOLE HYDROCHLORIDE
Created by
admin on Fri Dec 15 15:25:20 UTC 2023 , Edited by admin on Fri Dec 15 15:25:20 UTC 2023
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PRIMARY | Description: A white or almost white, crystalline powder. Solubility: Freely soluble in water; soluble in ethanol (~750 g/L) TS; slightly soluble in dichloromethane R. Category: Anthelminthic. Storage: Levamisole hydrochloride should be kept in a well-closed container, protected from light. Requirement: Levamisole hydrochloride contains not less than 98.5% and not more than 101.0% of C11H12N2S,HCl, calculated with reference to the dried substance. | ||
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DTXSID7047518
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CHEMBL1454
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177023
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DL9055K809
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DL9055K809
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1359302
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27944
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SUB02902MIG
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m6781
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227227
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100000088106
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240-654-6
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ACTIVE MOIETY
SUBSTANCE RECORD