AZEPEXOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H15N3O
Molecular Weight	181.2349
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1CCC2=C(CC1)N=C(N)O2

InChI

InChIKey=ZNXAJGZPUQOEDZ-UHFFFAOYSA-N

InChI=1S/C9H15N3O/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7/h2-6H2,1H3,(H2,10,11)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2866788 | https://www.ncbi.nlm.nih.gov/pubmed/6814471

Azepexole (or previously known as B-HT 933), a selective alpha 2-adrenoceptor agonist that was studied for the man with physiological tremor. It was shown that the drug produced sedation compared to placebo but not when compared to pre-treatment values. Some studies also have revealed the anti-tussive and antihypertensive properties of azepexole.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-2 113 Target ID: CHEMBL2095158 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2547487 \| https://www.ncbi.nlm.nih.gov/pubmed/1970494 \| https://www.ncbi.nlm.nih.gov/pubmed/7541362	Agonist 2678

PubMed

Title	Date	PubMed
		252159909
Antagonistic effects of S9871 or (imidazolinyl-2)-2-dihydro 2,3 benzofurane and its stereoisomers on some central and peripheral actions of alpha 2-agonists.	1985 Oct	2865936
Studies on the protective effect of azepexole on ouabain-induced cardiac arrhythmias and lethality in guinea-pig.	1995 Apr 4	7541362
Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats.	2009 Aug 15	19527708

Patents

Sample Use Guides

In Vivo Use Guide

azepexole 10 mg

Route of Administration: Oral

Name

Type

Language

AZEPEXOLE

Official Name

English

2-AMINO-6-ETHYL-5,6,7,8-TETRAHYDRO-4H-OXAZOLO(4,5-D)AZEPINE

Systematic Name

English

AZEPEXOLE [MART.]

Common Name

English

azepexole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709