AZEPEXOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H15N3O
Molecular Weight	181.2349
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN1CCC2=C(CC1)N=C(N)O2

InChI

InChIKey=ZNXAJGZPUQOEDZ-UHFFFAOYSA-N

InChI=1S/C9H15N3O/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7/h2-6H2,1H3,(H2,10,11)

HIDE SMILES / InChI

Molecular Formula	C9H15N3O
Molecular Weight	181.2349
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2866788 | https://www.ncbi.nlm.nih.gov/pubmed/6814471

Azepexole (or previously known as B-HT 933), a selective alpha 2-adrenoceptor agonist that was studied for the man with physiological tremor. It was shown that the drug produced sedation compared to placebo but not when compared to pre-treatment values. Some studies also have revealed the anti-tussive and antihypertensive properties of azepexole.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor alpha-2 114 Target ID: CHEMBL2095158 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2547487 \| https://www.ncbi.nlm.nih.gov/pubmed/1970494 \| https://www.ncbi.nlm.nih.gov/pubmed/7541362	Agonist 2752

PubMed

Title	Date	PubMed
Pharmacological characterization of the inhibition by moxonidine and agmatine on the cardioaccelerator sympathetic outflow in pithed rats.	2009-08-15	19527708
Studies on the protective effect of azepexole on ouabain-induced cardiac arrhythmias and lethality in guinea-pig.	1995-04-04	7541362
Antagonistic effects of S9871 or (imidazolinyl-2)-2-dihydro 2,3 benzofurane and its stereoisomers on some central and peripheral actions of alpha 2-agonists.	1985-10	2865936

Patents

Sample Use Guides

In Vivo Use Guide

azepexole 10 mg

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Wed Apr 02 08:20:11 GMT 2025` Edited by `admin` on `Wed Apr 02 08:20:11 GMT 2025`
Record UNII	DGB112538O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AZEPEXOLE [MART.]

Preferred Name

English

AZEPEXOLE

Official Name

English

2-AMINO-6-ETHYL-5,6,7,8-TETRAHYDRO-4H-OXAZOLO(4,5-D)AZEPINE

Systematic Name

English

azepexole [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29709