U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C12H24O11
Molecular Weight 344.3124
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MALTITOL

SMILES

[H][C@@](O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)([C@H](O)CO)[C@H](O)[C@@H](O)CO

InChI

InChIKey=VQHSOMBJVWLPSR-WUJBLJFYSA-N
InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9-,10+,11+,12+/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.nutrientsreview.com/carbs/sugar-alcohols-maltitol.html | http://www.polyols-eu.com/maltitol

Maltitol is a sugar alcohol, or polyol. Small amounts of maltitol occur naturally in chicory leaves and in roasted malt. Commercially, maltitol is produced from the starch of cereals such as corn, potatoes and wheat. Manufacturers use the catalytic hydrogenation of D-maltose to make a hydrogenated disaccharide consisting of a glucose molecule and a sorbitol molecule bound together. Maltitol is used as a low-calorie sweetener, humectant, thickening agent and texturizer in candies, chocolates, baked goods, ice creams, chewing gums and pan-coated tablets. In the European Union maltitol is labeled as E number E965.

CNS Activity

Approval Year

1990
108
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 69.0 mM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Effects of oral administration of maltitol on plasma glucose, plasma sorbitol, and serum insulin levels in man.
1986 Mar 17
Carbohydrate-controlled precipitation of apatite with coprecipitation of organic molecules in human saliva: stabilizing role of polyols.
1989 Apr
A high-performance liquid chromatography method for the analysis of picomole amounts of oligosaccharides.
1989 May 1
Metabolic fate of ingested [14C]-maltitol in man.
1991 Oct
Polyol-combinant saliva stimulants: a 4-month pilot study in young adults.
1998 Apr
Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties.
2003 Dec
Comparative relaxation dynamics of glucose and maltitol.
2006 Sep
Decreased salivary uptake of [14C]-xylitol after a four-week xylitol chewing gum regimen.
2007
Long-term effect of xylitol gum use on mutans streptococci in adults.
2007
Influence of carrier on the performance of dry powder inhalers.
2007 Apr 4
Improved postprandial response and feeling of satiety after consumption of low-calorie muffins with maltitol and high-amylose corn starch.
2007 Aug
In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen.
2007 Jan 10
Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum.
2007 Mar
Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.
2007 Sep
Stability of low concentrations of guanine-based antivirals in sucrose or maltitol solutions.
2007 Sep 5
Ecology of lactobacilli in the oral cavity: a review of literature.
2008
Protection of liposomes against fusion during drying by oligosaccharides is not predicted by the calorimetric glass transition temperatures of the dry sugars.
2008 Apr
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects.
2008 Aug
High pressure study on molecular mobility of leucrose.
2008 Aug 28
Behavioral analyses of sugar processing in choice, feeding, and learning in larval Drosophila.
2008 Jul
Xylitol gummy bear snacks: a school-based randomized clinical trial.
2008 Jul 25
Hydrophilic interaction chromatography/electrospray mass spectrometry analysis of carbohydrate-related metabolites from Arabidopsis thaliana leaf tissue.
2008 May
Impact of sugar replacers on cognitive performance and function in rats.
2008 Nov
Near-infrared analysis of hydrogen-bonding in glass- and rubber-state amorphous saccharide solids.
2009
Consistent evidence to support the use of xylitol- and sorbitol-containing chewing gum to prevent dental caries.
2009
Controversies around Xylitol.
2009 Apr
Isoconversional kinetics of glass aging.
2009 Apr 9
Standards of medical care in diabetes--2009.
2009 Jan
Fructan and its relationship to abiotic stress tolerance in plants.
2009 Jul
Suppressive response of confections containing the extractive from leaves of Morus Alba on postprandial blood glucose and insulin in healthy human subjects.
2009 Jul 14
Effects of polyols on the stability of whey proteins in intermediate-moisture food model systems.
2009 Mar 25
Recent advances in synthetic bioelastomers.
2009 Nov 20
Preparation and evaluation of medicinal carbon tablets with different saccharides as binders.
2009 Oct
Molecular and cellular designs of insect taste receptor system.
2010
Influences of casein hydrolysate ingestion on cerebral activity, autonomic nerve activity, and anxiety.
2010
Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review.
2010
Preparation and evaluation of medicinal carbon oral films.
2010 Apr
Molecular gastronomy: a new emerging scientific discipline.
2010 Apr 14
Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols.
2010 Apr 15
A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets.
2010 Aug
[Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
2010 Dec
Preparation of orally disintegrating tablets with taste-masking function: masking effect in granules prepared with correctives using the dry granulation method and evaluation of tablets prepared using the taste-masked granules.
2010 Jan
[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods].
2010 Jan
Standards of medical care in diabetes--2010.
2010 Jan
Predicting Arabidopsis freezing tolerance and heterosis in freezing tolerance from metabolite composition.
2010 Jan
The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population.
2010 Nov
Short-term digestive tolerance of chocolate formulated with maltitol in children.
2010 Nov
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509).
2010 Nov 30
[Comparative effects of the maltitol chewing gums on reducing plaque].
2010 Oct
A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition.
2010 Sep
Patents

Patents

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Sample Use Guides

In Vivo Use Guide
5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia in a mouse high-fat diet model.
Route of Administration: Oral
In Vitro Use Guide
Maltitol (1.25, 2.5, and 5 mg/mL) has a weak genotoxic potential and it appears non-cytotoxic to human peripheral lymphocytes in vitro.
Name Type Language
MALTITOL
EP   FCC   II   INCI   MART.   USP-RS  
INCI  
Official Name English
MALTITOL [II]
Common Name English
INS-965(I)
Code English
CERESTAR 16303
Common Name English
AMALTY MR 100
Common Name English
MALTITOL SOLUTION [NF]
Common Name English
SWEETPEARL P 200
Common Name English
MALTITOL SOLUTION
Common Name English
MALTISWEET 3145
Common Name English
MALBIT CH 16385
Common Name English
MALTITOL [FCC]
Common Name English
MALTITOL [INCI]
Common Name English
MALTITOL [EP MONOGRAPH]
Common Name English
MALTITOL [MART.]
Common Name English
HYDROGENATED HIGH MALTOSE-CONTENT GLUCOSE SYRUP
Common Name English
LYCASIN HBC
Common Name English
MALTIDEX CH 16385
Common Name English
INS NO.965(I)
Code English
DRIED MALTITOL SYRUP
Common Name English
MALTITOL SYRUP POWDER
Common Name English
HYDROGENATED MALTOSE
Common Name English
MALTITOL [USP-RS]
Common Name English
E-965(I)
Code English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-965(I)
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
DSLD 3248 (Number of products:4)
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
JECFA EVALUATION INS-965(I)
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
NCI_THESAURUS C283
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
Code System Code Type Description
HSDB
7971
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
ChEMBL
CHEMBL63558
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
MESH
C010745
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
ECHA (EC/EINECS)
209-567-0
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
EPA CompTox
DTXSID0044444
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
RS_ITEM_NUM
1374907
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
RXCUI
1363049
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY RxNorm
PUBCHEM
493591
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
NCI_THESAURUS
C77138
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
DAILYMED
D65DG142WK
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
EVMPD
SUB12136MIG
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
FDA UNII
D65DG142WK
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
WIKIPEDIA
MALTITOL
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
CAS
585-88-6
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
SMS_ID
100000080142
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
CHEBI
68428
Created by admin on Fri Dec 15 15:30:15 GMT 2023 , Edited by admin on Fri Dec 15 15:30:15 GMT 2023
PRIMARY
SUBSTANCE RECORD
Structure of MALTITOL
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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