Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C12H24O11 |
Molecular Weight | 344.3124 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@](O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)([C@H](O)CO)[C@H](O)[C@@H](O)CO
InChI
InChIKey=VQHSOMBJVWLPSR-WUJBLJFYSA-N
InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9-,10+,11+,12+/m0/s1
Molecular Formula | C12H24O11 |
Molecular Weight | 344.3124 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: http://nfscfaculty.tamu.edu/talcott/courses/FSTC605/Food%20Product%20Design/Maltitol.pdfCurator's Comment: Description was created based on several sources, including
http://www.nutrientsreview.com/carbs/sugar-alcohols-maltitol.html | http://www.polyols-eu.com/maltitol
Sources: http://nfscfaculty.tamu.edu/talcott/courses/FSTC605/Food%20Product%20Design/Maltitol.pdf
Curator's Comment: Description was created based on several sources, including
http://www.nutrientsreview.com/carbs/sugar-alcohols-maltitol.html | http://www.polyols-eu.com/maltitol
Maltitol is a sugar alcohol, or polyol. Small amounts of maltitol occur naturally in chicory leaves and in roasted malt. Commercially, maltitol
is produced from the starch of cereals such as corn, potatoes and wheat. Manufacturers use the catalytic hydrogenation of D-maltose to make a hydrogenated disaccharide consisting of a glucose molecule and a sorbitol molecule bound together. Maltitol is used as a low-calorie sweetener, humectant, thickening agent and texturizer in candies, chocolates, baked goods, ice creams, chewing gums and pan-coated tablets. In the European Union maltitol is labeled as E number E965.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2074 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8619618 |
69.0 mM [Ki] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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Effects of oral administration of maltitol on plasma glucose, plasma sorbitol, and serum insulin levels in man. | 1986 Mar 17 |
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A high-performance liquid chromatography method for the analysis of picomole amounts of oligosaccharides. | 1989 May 1 |
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Metabolic fate of ingested [14C]-maltitol in man. | 1991 Oct |
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Polyol-combinant saliva stimulants: a 4-month pilot study in young adults. | 1998 Apr |
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Developing a dynamic pharmacophore model for HIV-1 integrase. | 2000 Jun 1 |
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Plasticized waxy maize starch: effect of polyols and relative humidity on material properties. | 2002 Sep-Oct |
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Cloning and characterization of two alpha-glucosidases from Bifidobacterium adolescentis DSM20083. | 2003 Mar |
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Chemoenzymatically synthesized glycoconjugate polymers. | 2003 Mar-Apr |
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Evaluation of critical formulation factors in the development of a rapidly dispersing captopril oral dosage form. | 2003 Oct |
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Alternative sugars as potential carriers for dry powder inhalations. | 2004 Feb 11 |
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Characteristics of erythritol and formulation of a novel coating with erythritol termed thin-layer sugarless coating. | 2004 Jul 8 |
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Enzymatic, spectrophotometric determination of glucose, fructose, sucrose, and inulin/oligofructose in foods. | 2004 Sep-Oct |
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The effect of liquorice extract-containing starch gel on the amount and microbial composition of plaque. | 2006 Jun |
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Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. | 2006 Mar 24 |
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Comparative relaxation dynamics of glucose and maltitol. | 2006 Sep |
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Long-term effect of xylitol gum use on mutans streptococci in adults. | 2007 |
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Influence of carrier on the performance of dry powder inhalers. | 2007 Apr 4 |
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Improved postprandial response and feeling of satiety after consumption of low-calorie muffins with maltitol and high-amylose corn starch. | 2007 Aug |
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In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen. | 2007 Jan 10 |
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Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. | 2007 Mar |
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Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans. | 2007 Sep |
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Stability of low concentrations of guanine-based antivirals in sucrose or maltitol solutions. | 2007 Sep 5 |
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High pressure study on molecular mobility of leucrose. | 2008 Aug 28 |
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Behavioral analyses of sugar processing in choice, feeding, and learning in larval Drosophila. | 2008 Jul |
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Xylitol gummy bear snacks: a school-based randomized clinical trial. | 2008 Jul 25 |
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Consistent evidence to support the use of xylitol- and sorbitol-containing chewing gum to prevent dental caries. | 2009 |
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Isoconversional kinetics of glass aging. | 2009 Apr 9 |
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Suppressive response of confections containing the extractive from leaves of Morus Alba on postprandial blood glucose and insulin in healthy human subjects. | 2009 Jul 14 |
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Effects of polyols on the stability of whey proteins in intermediate-moisture food model systems. | 2009 Mar 25 |
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Recent advances in synthetic bioelastomers. | 2009 Nov 20 |
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Influences of casein hydrolysate ingestion on cerebral activity, autonomic nerve activity, and anxiety. | 2010 |
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Preparation and evaluation of medicinal carbon oral films. | 2010 Apr |
|
Molecular gastronomy: a new emerging scientific discipline. | 2010 Apr 14 |
|
Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols. | 2010 Apr 15 |
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A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets. | 2010 Aug |
|
[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods]. | 2010 Jan |
|
[Comparative effects of the maltitol chewing gums on reducing plaque]. | 2010 Oct |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26061453
5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia in a mouse high-fat diet model.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16777705
Maltitol (1.25, 2.5, and 5 mg/mL) has a weak genotoxic potential and it appears non-cytotoxic to human peripheral lymphocytes in vitro.
Substance Class |
Chemical
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Record UNII |
D65DG142WK
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Record Status |
Validated (UNII)
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CODEX ALIMENTARIUS (GSFA) |
INS-965(I)
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DSLD |
3248 (Number of products:4)
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JECFA EVALUATION |
INS-965(I)
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NCI_THESAURUS |
C283
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7971
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CHEMBL63558
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C010745
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209-567-0
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DTXSID0044444
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1374907
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1363049
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493591
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C77138
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D65DG142WK
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SUB12136MIG
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D65DG142WK
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MALTITOL
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585-88-6
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100000080142
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68428
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Related Record | Type | Details | ||
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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