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Details

Stereochemistry ABSOLUTE
Molecular Formula C12H24O11
Molecular Weight 344.3124
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MALTITOL

SMILES

OC[C@H](O)[C@@H](O)[C@H](O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)CO

InChI

InChIKey=VQHSOMBJVWLPSR-WUJBLJFYSA-N
InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9-,10+,11+,12+/m0/s1

HIDE SMILES / InChI
Molecular Formula C12H24O11
Molecular Weight 344.3124
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 9 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.nutrientsreview.com/carbs/sugar-alcohols-maltitol.html | http://www.polyols-eu.com/maltitol

Maltitol is a sugar alcohol, or polyol. Small amounts of maltitol occur naturally in chicory leaves and in roasted malt. Commercially, maltitol is produced from the starch of cereals such as corn, potatoes and wheat. Manufacturers use the catalytic hydrogenation of D-maltose to make a hydrogenated disaccharide consisting of a glucose molecule and a sorbitol molecule bound together. Maltitol is used as a low-calorie sweetener, humectant, thickening agent and texturizer in candies, chocolates, baked goods, ice creams, chewing gums and pan-coated tablets. In the European Union maltitol is labeled as E number E965.

CNS Activity

Approval Year

1990
111
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 69.0 mM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method].
2010-12
Complete genome sequence of Nocardiopsis dassonvillei type strain (IMRU 509).
2010-11-30
The influence of fruit load on the tomato pericarp metabolome in a Solanum chmielewskii introgression line population.
2010-11
Short-term digestive tolerance of chocolate formulated with maltitol in children.
2010-11
[Comparative effects of the maltitol chewing gums on reducing plaque].
2010-10
A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition.
2010-09
A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets.
2010-08
Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols.
2010-04-15
Molecular gastronomy: a new emerging scientific discipline.
2010-04-14
Preparation and evaluation of medicinal carbon oral films.
2010-04
Preparation of orally disintegrating tablets with taste-masking function: masking effect in granules prepared with correctives using the dry granulation method and evaluation of tablets prepared using the taste-masked granules.
2010-01
[Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods].
2010-01
Standards of medical care in diabetes--2010.
2010-01
Predicting Arabidopsis freezing tolerance and heterosis in freezing tolerance from metabolite composition.
2010-01
Molecular and cellular designs of insect taste receptor system.
2010
Influences of casein hydrolysate ingestion on cerebral activity, autonomic nerve activity, and anxiety.
2010
Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review.
2010
Recent advances in synthetic bioelastomers.
2009-11-20
Preparation and evaluation of medicinal carbon tablets with different saccharides as binders.
2009-10
Suppressive response of confections containing the extractive from leaves of Morus Alba on postprandial blood glucose and insulin in healthy human subjects.
2009-07-14
Fructan and its relationship to abiotic stress tolerance in plants.
2009-07
Isoconversional kinetics of glass aging.
2009-04-09
Controversies around Xylitol.
2009-04
Effects of polyols on the stability of whey proteins in intermediate-moisture food model systems.
2009-03-25
Standards of medical care in diabetes--2009.
2009-01
Near-infrared analysis of hydrogen-bonding in glass- and rubber-state amorphous saccharide solids.
2009
Consistent evidence to support the use of xylitol- and sorbitol-containing chewing gum to prevent dental caries.
2009
Impact of sugar replacers on cognitive performance and function in rats.
2008-11
High pressure study on molecular mobility of leucrose.
2008-08-28
Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects.
2008-08
Xylitol gummy bear snacks: a school-based randomized clinical trial.
2008-07-25
Behavioral analyses of sugar processing in choice, feeding, and learning in larval Drosophila.
2008-07
Hydrophilic interaction chromatography/electrospray mass spectrometry analysis of carbohydrate-related metabolites from Arabidopsis thaliana leaf tissue.
2008-05
Protection of liposomes against fusion during drying by oligosaccharides is not predicted by the calorimetric glass transition temperatures of the dry sugars.
2008-04
Ecology of lactobacilli in the oral cavity: a review of literature.
2008
Stability of low concentrations of guanine-based antivirals in sucrose or maltitol solutions.
2007-09-05
Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.
2007-09
Improved postprandial response and feeling of satiety after consumption of low-calorie muffins with maltitol and high-amylose corn starch.
2007-08
Influence of carrier on the performance of dry powder inhalers.
2007-04-04
Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum.
2007-03
In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen.
2007-01-10
Decreased salivary uptake of [14C]-xylitol after a four-week xylitol chewing gum regimen.
2007
Long-term effect of xylitol gum use on mutans streptococci in adults.
2007
Comparative relaxation dynamics of glucose and maltitol.
2006-09
Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties.
2003-12
Polyol-combinant saliva stimulants: a 4-month pilot study in young adults.
1998-04
Metabolic fate of ingested [14C]-maltitol in man.
1991-10
A high-performance liquid chromatography method for the analysis of picomole amounts of oligosaccharides.
1989-05-01
Carbohydrate-controlled precipitation of apatite with coprecipitation of organic molecules in human saliva: stabilizing role of polyols.
1989-04
Effects of oral administration of maltitol on plasma glucose, plasma sorbitol, and serum insulin levels in man.
1986-03-17
Patents

Patents

JP1020063A
1
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4
JP2000204035A
1
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1
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JP2000264835A
1
JP2000270787A
1
JP2000273489A
1
JP2000281562A
1
JP2000300190A
1
JP2000505312A
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JP2001039857A
1
JP2001039860A
1
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1
JP2001123194A
3
JP2001128635A
1
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1
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1
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1
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1
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1
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1
JP2002121133A
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JP2002191320A
1
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JP2002234895A
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JP2002253167A
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JP2002514212A
1

Sample Use Guides

In Vivo Use Guide
5.0% maltitol for 8 weeks significantly suppressed weight gain, hepatic fatty degeneration, hyperglycemia, and hypercholesterolemia in a mouse high-fat diet model.
Route of Administration: Oral
In Vitro Use Guide
Maltitol (1.25, 2.5, and 5 mg/mL) has a weak genotoxic potential and it appears non-cytotoxic to human peripheral lymphocytes in vitro.
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:59:19 GMT 2025
Edited
by admin
on Mon Mar 31 17:59:19 GMT 2025
Record UNII
D65DG142WK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MALTITOL
EP   FCC   II   INCI   MART.   USP-RS  
INCI  
Official Name English
E-965(I)
Preferred Name English
MALTITOL [II]
Common Name English
INS-965(I)
Code English
CERESTAR 16303
Common Name English
AMALTY MR 100
Common Name English
MALTITOL SOLUTION [NF]
Common Name English
SWEETPEARL P 200
Common Name English
MALTITOL SOLUTION
Common Name English
MALTISWEET 3145
Common Name English
MALBIT CH 16385
Common Name English
MALTITOL [FCC]
Common Name English
MALTITOL [EP MONOGRAPH]
Common Name English
MALTITOL [MART.]
Common Name English
HYDROGENATED HIGH MALTOSE-CONTENT GLUCOSE SYRUP
Common Name English
LYCASIN HBC
Common Name English
MALTIDEX CH 16385
Common Name English
INS NO.965(I)
Code English
DRIED MALTITOL SYRUP
Common Name English
MALTITOL SYRUP POWDER
Common Name English
HYDROGENATED MALTOSE
Common Name English
MALTITOL [USP-RS]
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-965(I)
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
DSLD 3248 (Number of products:4)
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
JECFA EVALUATION INS-965(I)
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
NCI_THESAURUS C283
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
Code System Code Type Description
HSDB
7971
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
ChEMBL
CHEMBL63558
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
MESH
C010745
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
ECHA (EC/EINECS)
209-567-0
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
EPA CompTox
DTXSID0044444
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
RS_ITEM_NUM
1374907
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
RXCUI
1363049
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY RxNorm
PUBCHEM
493591
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
NCI_THESAURUS
C77138
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
DAILYMED
D65DG142WK
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
EVMPD
SUB12136MIG
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
FDA UNII
D65DG142WK
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
WIKIPEDIA
MALTITOL
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
CAS
585-88-6
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
SMS_ID
100000080142
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
CHEBI
68428
Created by admin on Mon Mar 31 17:59:19 GMT 2025 , Edited by admin on Mon Mar 31 17:59:19 GMT 2025
PRIMARY
Related Record Type Details
Structure of MALTOTRIITOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of SORBITOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
NIH
NCATS
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