Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C51H84O22 |
| Molecular Weight | 1049.1995 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 31 / 31 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@](O)(CC[C@@H](C)CO[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)O2)O[C@]7([H])O[C@H](CO)[C@@H](O[C@]8([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O[C@]9([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O
InChI
InChIKey=LVTJOONKWUXEFR-UEZXSUPNSA-N
InChI=1S/C51H84O22/c1-20(19-65-45-39(60)38(59)35(56)30(17-52)69-45)9-14-51(64)21(2)32-29(73-51)16-28-26-8-7-24-15-25(10-12-49(24,5)27(26)11-13-50(28,32)6)68-48-44(72-47-41(62)37(58)34(55)23(4)67-47)42(63)43(31(18-53)70-48)71-46-40(61)36(57)33(54)22(3)66-46/h7,20-23,25-48,52-64H,8-19H2,1-6H3/t20-,21+,22+,23+,25+,26-,27+,28+,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39-,40-,41-,42+,43-,44-,45-,46+,47+,48-,49+,50+,51-/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11988850 | https://www.ncbi.nlm.nih.gov/pubmed/12804079
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/11988850 | https://www.ncbi.nlm.nih.gov/pubmed/12804079
Protodioscin is a steroidal saponin compound found in a number of plant species, most notably in the Tribulus, Trigonella and Dioscorea families. Extracts from T. terrestris standardised have been demonstrated to produce proerectile effects in isolated tissues and aphrodisiac action in several animal species. Protodioscin have shown cytotoxic effects against a number of leukemia and solid tumors cell lines.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Total synthesis of methyl protodioscin: a potent agent with antitumor activity. | 2003 May 2 |
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| Microbial metabolism of pseudoprotodioscin. | 2004 Jul |
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| Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety. | 2004 Jul 12 |
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| Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid. | 2006 Jul |
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| Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. | 2006 Sep 8 |
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| Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears. | 2010 Nov-Dec |
Patents
Sample Use Guides
24 New Zealand white rabbits were divided randomly into four groups of six each. Group I served control and was treated with vehicle alone. Groups II, III, IV were treated with three different concentrations of Tribulus terrestris extracts (2.5, 5 and 10 mg/kg, respectively), orally for 8 weeks.
Route of Administration:
Oral
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DSLD |
1157 (Number of products:8)
Created by
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DTXSID901021361
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8588
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Protodioscin
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55056-80-9
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441891
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D0LC3PH24P
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SUBSTANCE RECORD
