BRIFENTANIL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H29FN6O3.ClH
Molecular Weight	456.942
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN1N=NN(CCN2CC[C@H]([C@@H](C)C2)N(C(=O)COC)C3=CC=CC=C3F)C1=O

InChI

InChIKey=VHXNDLUDRKRBCQ-KPVRICSOSA-N

InChI=1S/C20H29FN6O3.ClH/c1-4-25-20(29)26(23-22-25)12-11-24-10-9-17(15(2)13-24)27(19(28)14-30-3)18-8-6-5-7-16(18)21;/h5-8,15,17H,4,9-14H2,1-3H3;1H/t15-,17+;/m0./s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1874883 | https://www.ncbi.nlm.nih.gov/pubmed/1798508 | https://www.ncbi.nlm.nih.gov/pubmed/2170652 | https://www.drugbank.ca/drugs/DB09172

Brifentanii, a potent narcotic analgesic structurally similar to alfentanil, that was studied in clinical trials in the early 1990s. The effects of brifentanil are very similar to those of alfentanil, with strong but short lasting analgesia and sedation, and particularly notable itching and respiratory depression. Side effects of Brifentanii are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening.

Originator

Approval Year

Patents

Name

Type

Language

BRIFENTANIL HYDROCHLORIDE

Official Name

English

A 3331

Preferred Name

English

ACETAMIDE, N-(1-(2-(4-ETHYL-4,5-DIHYDRO-5-OXO-1H-TETRAZOL-1-YL)ETHYL)-3-METHYL-4-PIPERIDINYL)-N-(2-FLUOROPHENYL)-2-METHOXY-, MONOHYDROCHLORIDE, CIS-(±)-

Common Name

English

(±)-CIS-N-(1-(2-(4-ETHYL-5-OXO-2-TETRAZOLIN-1-YL)ETHYL)-3-METHYL-4-PIPERIDYL)-2'-FLUORO-2-METHOXYACETANILIDE MONOHYDROCHLORIDE

Systematic Name

English

Brifentanil hydrochloride [WHO-DD]

Common Name

English

BRIFENTANIL HYDROCHLORIDE [USAN]

Common Name

English

A-3331

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C241