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Details

Stereochemistry ACHIRAL
Molecular Formula C24H31N3O2S
Molecular Weight 425.587
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARPHENAZINE

SMILES

CCC(=O)C1=CC=C2SC3=CC=CC=C3N(CCCN4CCN(CCO)CC4)C2=C1

InChI

InChIKey=XZSMZRXAEFNJCU-UHFFFAOYSA-N
InChI=1S/C24H31N3O2S/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28H,2,5,10-17H2,1H3

HIDE SMILES / InChI

Description

Carfenazine (brand name Proketazine) is an antipsychotic and tranquilizer of the phenothiazine group. It is used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Proketazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. The following is a list of possible side effects that may occur from all constituting ingredients of Proketazine: akathisia, tardive dyskinesia, extrapyramidal symptoms, allergic purpura.

CNS Activity

Originator

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROKETAZINE
PubMed

PubMed

TitleDatePubMed
Carphenazine in the intensive care of chronically ill psychotics.
1967 Aug
Evaluation of carphenazine in hospitalized schizophrenic women.
1967 Feb
Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial.
1967 Nov
Patents

Sample Use Guides

In Vivo Use Guide
First week, 25 mg. t.i.d.; second week, 50 mg. t.i.d.; third week, 75 mg. t.i.d.; fourth week, 100 mg. t.i.d.; fifth week and thereafter, 100 mg. q.i.d.
Route of Administration: Oral
Name Type Language
CARPHENAZINE
MI  
Common Name English
CARPHENAZINE [MI]
Common Name English
CARFENAZINE
INN   WHO-DD  
INN  
Official Name English
CARFENAZINE [WHO-DD]
Common Name English
Code System Code Type Description
CAS
2622-30-2
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
NCI_THESAURUS
C73285
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
MERCK INDEX
M1057
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
220-072-9
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
ChEMBL
CHEMBL1201328
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
IUPHAR
7140
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
EPA CompTox
2622-30-2
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
INN
1179
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY
PUBCHEM
18104
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY SWITZERF
EVMPD
SUB06625MIG
Created by admin on Tue Mar 06 12:11:55 UTC 2018 , Edited by admin on Tue Mar 06 12:11:55 UTC 2018
PRIMARY