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Details

Stereochemistry ACHIRAL
Molecular Formula C24H31N3O2S.2C4H4O4
Molecular Weight 657.731
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 2
Charge 0

SHOW SMILES / InChI
Structure of CARPHENAZINE MALEATE

SMILES

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.CCC(=O)C1=CC=C2SC3=C(C=CC=C3)N(CCCN4CCN(CCO)CC4)C2=C1

InChI

InChIKey=TVPJGGZLZLUPOB-SPIKMXEPSA-N
InChI=1S/C24H31N3O2S.2C4H4O4/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28;2*5-3(6)1-2-4(7)8/h3-4,6-9,18,28H,2,5,10-17H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

HIDE SMILES / InChI

Molecular Formula C4H4O4
Molecular Weight 116.0722
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula C24H31N3O2S
Molecular Weight 425.587
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Carfenazine (brand name Proketazine) is an antipsychotic and tranquilizer of the phenothiazine group. It is used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients. Proketazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. The following is a list of possible side effects that may occur from all constituting ingredients of Proketazine: akathisia, tardive dyskinesia, extrapyramidal symptoms, allergic purpura.

CNS Activity

Originator

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PROKETAZINE
PubMed

PubMed

TitleDatePubMed
Carphenazine in the treatment of schizophrenic psychoses. Controlled clinical trial.
1967 Nov
Patents

Sample Use Guides

In Vivo Use Guide
First week, 25 mg. t.i.d.; second week, 50 mg. t.i.d.; third week, 75 mg. t.i.d.; fourth week, 100 mg. t.i.d.; fifth week and thereafter, 100 mg. q.i.d.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Tue Oct 22 06:07:03 UTC 2019
Edited
by admin
on Tue Oct 22 06:07:03 UTC 2019
Record UNII
0HX1Z0A2MC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CARPHENAZINE MALEATE
ORANGE BOOK   USAN  
USAN  
Official Name English
1-(10-(3-(4-(2-HYDROXYETHYL)PIPERAZIN-1-YL)PROPYL)-10H-PHENOTHIAZIN-2-YL)PROPAN-1-ONE DI((2Z)-BUT-2-ENEDIOATE) (SALT)
Common Name English
CARFENAZINE MALEATE [MART.]
Common Name English
PROKETAZINE
Brand Name English
CARFENAZINE MALEATE [WHO-DD]
Common Name English
CARPHENAZINE MALEATE [USAN]
Common Name English
CARPHENAZINE DIMALEATE [MI]
Common Name English
NSC-71755
Code English
CARFENAZINE MALEATE
MART.   WHO-DD  
Common Name English
1-PROPANONE, 1-(10-(3-(4-(2-HYDROXYETHYL)-1-PIPERAZINYL)PROPYL)-10H-PHENOTHIAZIN-2-YL)-, (2Z)-2-BUTENEDIOATE (1:2) (SALT)
Common Name English
1-(10-(3-(4-(2-HYDROXYETHYL)-1-PIPERAZINYL)PROPYL)PHENOTHIAZIN-2-YL)-1-PROPANONE MALEATE (1:2)
Systematic Name English
WY-2445
Code English
CARPHENAZINE DIMALEATE
MI  
Common Name English
CARPHENAZINE MALEATE [ORANGE BOOK]
Common Name English
1-PROPANONE, 1-(10-(3-(4-(2-HYDROXYETHYL)-1-PIPERAZINYL)PROPYL)-10H-PHENOTHIAZIN-2-YL)-, (Z)-2-BUTENEDIOATE (1:2)
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C740
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
NCI_THESAURUS C29710
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
Code System Code Type Description
EPA CompTox
2975-34-0
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
NCI_THESAURUS
C65289
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
CAS
2975-34-0
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
EVMPD
SUB01059MIG
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
PUBCHEM
6433356
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
ChEMBL
CHEMBL1201328
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
ECHA (EC/EINECS)
221-019-2
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY
MERCK INDEX
M1057
Created by admin on Tue Oct 22 06:07:03 UTC 2019 , Edited by admin on Tue Oct 22 06:07:03 UTC 2019
PRIMARY Merck Index
Related Record Type Details
PARENT -> SALT/SOLVATE
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY