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Details

Stereochemistry ACHIRAL
Molecular Formula C16H20N2O4S2.ClH
Molecular Weight 404.932
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRITINOL HYDROCHLORIDE ANHYDROUS

SMILES

Cl.CC1=NC=C(CSSCC2=CN=C(C)C(O)=C2CO)C(CO)=C1O

InChI

InChIKey=LZNSOAFXPYSLRQ-UHFFFAOYSA-N
InChI=1S/C16H20N2O4S2.ClH/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20;/h3-4,19-22H,5-8H2,1-2H3;1H

HIDE SMILES / InChI
Pyritinol is a semi natural analogue of water soluble vitamin B6. Pyritinol was synthetized way back in 1961 by Merck Laboratories. After years of research, it entered the market in the 1970s, where it was used for clinical applications – including treating stroke patients and those with Alzheimer’s. Since the 1990s, it has been sold as a nootropic dietary supplement in the United States and many other parts of the world. Pyritinol, unlike many other nootropics, has been approved for use as a medical treatment in countries around the world. Doctors in many European countries use Pyritinol to treat patients with chronic degenerative brain disorders – like dementia. Countries where Pyritinol is an approved treatment include Austria, Germany, France, Greece, Italy, and Portugal. France has approved the use of Pyritinol – but only as a treatment for rheumatoid arthritis. Pyritinol is not currently licensed for use in the United Kingdom, but in most other countries, it’s available online or through drug stores as an over the counter substance. Pyritinol is marketed under the brand names Encephabol, Encefabol and Cerbon 6. One of the known mechanisms of action of Pyritinol involves increasing choline uptake into your neurons and thereby increasing acetylcholine levels. Pyritinol is also a great effective precursor to dopamine, which is one of the neurotransmitter mood-boosters in the brain. Pyritinol has better conversion into the neurochemical. This drug increases dopamine, which can keep the brain from anxiety because a lower dopamine level is connected to mood disorders and depression.

Originator

Curator's Comment: Pyritinol was initially developed by Merck Laboratories in the year 1961 # Merck

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Encephabol

Approved Use

Indications: symptomatic treatment of chronic disorders of the brain function in dementia syndromes with the following symptoms: impaired memory and thinking, decreased concentration, fatigue, lack of incentives and motivation, affective disorders. Primary degenerative dementia, dementia of vascular origin and mixed forms. Symptomatic treatment of chronic disorders of mental disability. Post-traumatic encephalopathy. Cerebral atherosclerosis. The consequences of encephalitis. Mental retardation, tserebrastenichesky syndrome, encephalopathy in children.
Primary
Encephabol

Approved Use

Indications: symptomatic treatment of chronic disorders of the brain function in dementia syndromes with the following symptoms: impaired memory and thinking, decreased concentration, fatigue, lack of incentives and motivation, affective disorders. Primary degenerative dementia, dementia of vascular origin and mixed forms. Symptomatic treatment of chronic disorders of mental disability. Post-traumatic encephalopathy. Cerebral atherosclerosis. The consequences of encephalitis. Mental retardation, tserebrastenichesky syndrome, encephalopathy in children.
Primary
Encephabol

Approved Use

Encephabol stimulates the central nervous system and belongs to the group of drugs for treating Alzheimer's disease. USES Erradicate Physical and Psychological Weakness Treat Alzheimer's Disease Reduce Memory Impairment Get Rid of Hangovers Reduce Learning Disorders Sequelae of Craniocerebral Trauma
PubMed

PubMed

TitleDatePubMed
Stability-indicating methods for determination of pyritinol dihydrochloride in the presence of its precursor and degradation product by derivative spectrophotometry.
2005 Jan-Feb
Stability-indicating electrochemical methods for the determination of meclophenoxate hydrochloride and pyritinol dihydrochloride using ion-selective membrane electrodes.
2007 Jan
Pyritinol reduces nociception and oxidative stress in diabetic rats.
2008 Aug 20
Patents

Sample Use Guides

In Vivo Use Guide
Encephabol (Pyritinol) comes in coated tablets. The dosage depends on the severity of the patients condition. Tablets should be taken with meal and a large glass of water. Dosage for adults: 600 mg a day (2 tabs 3 times a day). Dosage for newborn infants: on the third day of life 20 mg a day during a month. Dosage for pediatric patients: 2 months: the dosage is increases 20 mg every next week until the daily dose will be 100 mg. 1-7 years old: 50-300 mg a day. 7 years old and over: 50-600 mg a day (1-2 tabs 1-3 times a day). In patients with chronic conditions the period of therapy should be no less than 8 weeks.
Route of Administration: Oral
In Vitro Use Guide
Pretreatment of rabbit peritoneal neutrophils with Pyritinol had an inhibitory effect on random migration or fMLP-activated chemotaxis at high concentrations (1 mM), and a slight potentiating effect at low concentrations (10 uM)
Name Type Language
PYRITINOL HYDROCHLORIDE ANHYDROUS
Common Name English
PYRITINOL DIHYDROCHLORIDE
Common Name English
ANHYDROUS PYRITINOL HYDROCHLORIDE [MART.]
Common Name English
5,5-DIHYDROXY-6,6-DIMETHYL-3,3-DITHIODIMETHYLENEBIS(4-PYRIDYLMETHANOL) DIHYDOCHLORIDE
Common Name English
PYRIDITOL
Systematic Name English
Pyritinol hydrochloride [WHO-DD]
Common Name English
4-PYRIDINEMETHANOL, 3,3'-(DITHIOBIS(METHYLENE))BIS(5-HYDROXY-6-METHYL-, DIHYDROCHLORIDE
Systematic Name English
PYRITHIOXIN HYDROCHLORIDE
Common Name English
4-PYRIDINEMETHANOL, 3,3'-(DITHIODIMETHYLENE)BIS(5-HYDROXY-6-METHYL-, DIHYDROCHLORIDE
Systematic Name English
4-PYRIDINEMETHANOL, 3,3'-(DITHIOBIS(METHYLENE))BIS(5-HYDROXY-6-METHYL-, HYDROCHLORIDE (1:2)
Systematic Name English
ANHYDROUS PYRITINOL HYDROCHLORIDE
MART.  
Common Name English
NSC-526973
Code English
Code System Code Type Description
PUBCHEM
12309456
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
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CAS
10049-83-9
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
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ECHA (EC/EINECS)
233-178-5
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
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EPA CompTox
DTXSID1046550
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
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FDA UNII
CFA914331M
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
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SMS_ID
100000085138
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
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NSC
526973
Created by admin on Sat Dec 16 05:40:44 GMT 2023 , Edited by admin on Sat Dec 16 05:40:44 GMT 2023
PRIMARY