FILAMINAST

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H20N2O4
Molecular Weight	292.3303
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of FILAMINAST

Structure Search

SMILES

COC1=CC=C(C=C1OC2CCCC2)C(\C)=N\OC(N)=O

InChI

InChIKey=STTRYQAGHGJXJJ-LICLKQGHSA-N

InChI=1S/C15H20N2O4/c1-10(17-21-15(16)18)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H2,16,18)/b17-10+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19281073 | https://www.ncbi.nlm.nih.gov/pubmed/8114002 | https://www.ncbi.nlm.nih.gov/pubmed/18660832

FILAMINAST is a phosphodiesterase 4 inhibitor with bronchorelaxant activity and selectivity of potential use in the treatment of asthma. However, its clinical development was discontinued due to lack of efficacy.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed

Patents

Patents

Sample Use Guides

In Vitro Use Guide

FILAMINAST was identified as a preferential inhibitor of phosphodiesterase (PDE) 4, possessing 36 times greater potency versus canine trachealis PDE4 than PDE3 (IC50, 4.2*10^-7 M and 1.5*10^-5 M, respectively).

Name

Type

Language

FILAMINAST

Official Name

English

PDA641

Code

English

PDA-641

Code

English

filaminast [INN]

Common Name

English

ETHANONE, 1-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)-, O-(AMINOCARBONYL)OXIME, (E)-

Common Name

English

3'-(CYCLOPENTYLOXY)-4'-METHOXYACETOPHENONE (E)-O-CARBAMOYLOXIME

Systematic Name

English

WAY-PDA-641

Code

English

FILAMINAST [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

Code System Code Type Description

USAN

GG-50

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PRIMARY

EVMPD

SUB07625MIG

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PUBCHEM

9578243

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ChEMBL

CHEMBL590754

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MESH

C085988

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INN

7485

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FDA UNII

CDD69JC61J

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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WIKIPEDIA

Filaminast

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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NCI_THESAURUS

C80612

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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CAS

141184-34-1

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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DRUG BANK

DB02660

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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EPA CompTox

DTXSID80869910

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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SMS_ID

100000080986

Created by admin on Fri Dec 15 15:34:26 GMT 2023 , Edited by admin on Fri Dec 15 15:34:26 GMT 2023

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ACTIVE MOIETY


					CDD69JC61J