PIPRADIMADOL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H37ClN2O2
Molecular Weight	421.016
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C1CCCCC1)C(=O)C(C)(C)C2(O)CCN(CCC3=C(Cl)C=CC=C3)CC2

InChI

InChIKey=CNIMNQJXZKALLC-UHFFFAOYSA-N

InChI=1S/C24H37ClN2O2/c1-23(2,22(28)26(3)20-10-5-4-6-11-20)24(29)14-17-27(18-15-24)16-13-19-9-7-8-12-21(19)25/h7-9,12,20,29H,4-6,10-11,13-18H2,1-3H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6181982 | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf | DOI: 10.1007/BF00771998 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 991, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Pipradimadol is a 4.4-disubstituted piperidine derivative which demonstrates, in animal experiments, effects typical for certain antidepressant and antiserotonin drugs. Pipradimadol is the central serotonin antagonist. Pipradimadol exhibits antinociceptive properties also. Behavioral tests reflect overall sedation after pipradimadol, decreased rectal temperature and locomotor activity; cataleptic effects of tetrabenazine are antagonized and noradrenaline as well as dopamine reuptake in vitro are slightly inhibited. Homovanillic acid, a metabolite of dopamine is strongly increased after pipradimadol in rat striatum. Pipradimadol was used as analgesic agent.

Approval Year

PubMed

Title	Date	PubMed
Human EEG slow-wave sleep increased by a serotonin antagonist.	1982 Nov	6181982
Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.	1983 Jan	6600791

Sample Use Guides

In Vivo Use Guide

200 mg was taken nightly for 6 nights

Route of Administration: Oral

Name

Type

Language

PIPRADIMADOL

Official Name

English

1-(O-CHLOROPHENETHYL)-N-CYCLOHEXYL-4-HYDROXY-N,.ALPHA.,.ALPHA.-TRIMETHYL-4-PIPERIDINEACETAMIDE

Common Name

English

pipradimadol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C267