TINORIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H20N2O2S
Molecular Weight	316.418
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=C(N)SC2=C1CCN(CC3=CC=CC=C3)C2

InChI

InChIKey=PFENFDGYVLAFBR-UHFFFAOYSA-N

InChI=1S/C17H20N2O2S/c1-2-21-17(20)15-13-8-9-19(11-14(13)22-16(15)18)10-12-6-4-3-5-7-12/h3-7H,2,8-11,18H2,1H3

HIDE SMILES / InChI

Description
Sources: http://www.obatinfo.com/2010/01/nonflamin.html
Curator's Comment: description was created based on several sources, including: http://www.obatapasaja.com/2015/05/komposisi-dosis-dan-harga-nonflamin.html http://www.ncbi.nlm.nih.gov/pubmed/702946

Tinoridine is a non-steroidal anti-inflammatory and analgesic agent. This agent has been proved pharmacologically to show antiedematous and analgesic actions. The mechanism of the anti-inflammatory action of Tinoridine is attributed to its biomembrane stabilizing action particularly on the lysosomes which are related to cell or tissue damage at the time of inflammation through the release of hydrolytic enzymes. Tinoridine may produce gastrointestinal disorders (nausea, loss of appetite, diarrhea, and constipation), vertigo drowsiness, dry mouth and itching.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
lipid oxidation 20 Target ID: GO:0034440 Sources: http://www.ncbi.nlm.nih.gov/pubmed/1242397 \| http://www.ncbi.nlm.nih.gov/pubmed/20972 \| http://www.ncbi.nlm.nih.gov/pubmed/3030074	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Inflammation after injury surgery, injury in urology 2 Sources: http://www.obatinfo.com/2010/01/nonflamin.html	Palliative	Approved 8429	Nonflamin Approved Use Tinoridine is indicated as anti-inflammatory agent after surgery injuries or injury in urology.
Acute upper respiratory tract inflammation 2 Sources: http://www.obatinfo.com/2010/01/nonflamin.html	Primary	Approved 8429	Nonflamin Approved Use Tinoridine is used to treat pharyngitis, laryngitis, tonsillitis.
Back pain 2 Sources: http://www.obatinfo.com/2010/01/nonflamin.html	Primary	Approved 8429	Nonflamin Approved Use For analgesic purpose, Tinoridine is used to treat back pain.
Lumbago 8 Sources: http://www.obatinfo.com/2010/01/nonflamin.html	Primary	Approved 8429	Nonflamin Approved Use For analgesic purpose, Tinoridine is used to treat lumbago.
Pain in chronic rheumatic disease 2 Sources: http://www.obatinfo.com/2010/01/nonflamin.html	Primary	Approved 8429	Nonflamin Approved Use Tinoridine is indicated to treat pain in chronic rheumatic diseases.

PubMed

Title	Date	PubMed
Ethyl 2-amino-6-benzyl-4,5,6,7-tetra-hydro-thieno[2,3-c]pyridine-3-carboxyl-ate.	2010 Dec 24	21522725

Patents

Sample Use Guides

In Vivo Use Guide

1-2 capsules 3 times a day

Route of Administration: Oral

In Vitro Use Guide

30 uM of Tinoridine HCl hydrochloride inhibited the Phospholipase C-induced lysosomal enzyme release from rat liver lysosomes.

Name

Type

Language

TINORIDINE

Official Name

English

tinoridine [INN]

Common Name

English

Y-3642

Code

English

NSC-158555

Code

English

Tinoridine [WHO-DD]

Common Name

English

Y 3642

Code

English

TINORIDINE [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C257