PHA-568487

O=C(N[C@H]1CN2CCC1CC2)C3=CC4=C(OCCO4)C=C3

InChIKey=LUVXHMJTVXZFPD-ZDUSSCGKSA-N

InChI=1S/C16H20N2O3/c19-16(17-13-10-18-5-3-11(13)4-6-18)12-1-2-14-15(9-12)21-8-7-20-14/h1-2,9,11,13H,3-8,10H2,(H,17,19)/t13-/m0/s1

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 3 (5-HT3) receptor 59 Target ID: CHEMBL2111332 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17011782	Binding Agent 1064		2.8 µM [Ki]
Neuronal acetylcholine receptor protein alpha-7 subunit 77 Target ID: CHEMBL2492 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17011782	Agonist 2678		44.0 nM [Ki]

PubMed

Title	Date	PubMed
First identification of benzo[ghi]naphtho[8,1,2-bcd]perylene as a product of fuel pyrolysis, using high-performance liquid chromatography with diode-array ultraviolet-visible absorbance detection and mass spectrometry.	2006 Sep 15	16814309
Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist.	2010 Aug	20642449
Resolving postoperative neuroinflammation and cognitive decline.	2011 Dec	22190370
Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia.	2014 Oct 1	25036424
Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.	2015 Mar 17	25365546
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.	2015 Oct 15	26206194
Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.	2017 Dec	27914011
α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass.	2017 Oct	28791395
In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia.	2018 Aug	29528142

Name

Type

Language

PHA-568487

Common Name

English

N-(3R)-1-AZABICYCLO(2.2.2)OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE

Systematic Name

English

1,4-BENZODIOXIN-6-CARBOXAMIDE, N-(3R)-1-AZABICYCLO(2.2.2)OCT-3-YL-2,3-DIHYDRO-

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID1047285

Created by admin on Fri Dec 15 16:37:08 GMT 2023 , Edited by admin on Fri Dec 15 16:37:08 GMT 2023

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FDA UNII

C9IF5SIJ2I

Created by admin on Fri Dec 15 16:37:08 GMT 2023 , Edited by admin on Fri Dec 15 16:37:08 GMT 2023

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PUBCHEM

9932000

Created by admin on Fri Dec 15 16:37:08 GMT 2023 , Edited by admin on Fri Dec 15 16:37:08 GMT 2023

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CAS

527680-56-4

Created by admin on Fri Dec 15 16:37:08 GMT 2023 , Edited by admin on Fri Dec 15 16:37:08 GMT 2023

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SUBSTANCE RECORD


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