Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H20N2O3 |
| Molecular Weight | 288.3416 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(N[C@H]1CN2CCC1CC2)C3=CC4=C(OCCO4)C=C3
InChI
InChIKey=LUVXHMJTVXZFPD-ZDUSSCGKSA-N
InChI=1S/C16H20N2O3/c19-16(17-13-10-18-5-3-11(13)4-6-18)12-1-2-14-15(9-12)21-8-7-20-14/h1-2,9,11,13H,3-8,10H2,(H,17,19)/t13-/m0/s1
| Molecular Formula | C16H20N2O3 |
| Molecular Weight | 288.3416 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Enantiomeric purity methods for three pharmaceutical compounds by electrokinetic capillary chromatography utilizing highly sulfated-gamma-cyclodextrin as the chiral selector. | 2006 Sep 15 |
|
| Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. | 2010 Aug |
|
| Resolving postoperative neuroinflammation and cognitive decline. | 2011 Dec |
|
| Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia. | 2014 Oct 1 |
|
| Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice. | 2015 Mar 17 |
|
| Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. | 2017 Dec |
|
| In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia. | 2018 Aug |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:37:08 GMT 2023
by
admin
on
Fri Dec 15 16:37:08 GMT 2023
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| Record UNII |
C9IF5SIJ2I
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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DTXSID1047285
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C9IF5SIJ2I
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9932000
Created by
admin on Fri Dec 15 16:37:08 GMT 2023 , Edited by admin on Fri Dec 15 16:37:08 GMT 2023
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527680-56-4
Created by
admin on Fri Dec 15 16:37:08 GMT 2023 , Edited by admin on Fri Dec 15 16:37:08 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> AGONIST |
(.ALPHA.7 NACHR) IN VITRO DATA KI = 8.8 +/- 1.3 NM
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