ENLOPLATIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H16N2O.C6H6O4.Pt
Molecular Weight	481.408
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Pt++].NCC1(CN)CCOCC1.[O-]C(=O)C2(CCC2)C([O-])=O

InChI

InChIKey=ASQRQYODAQUVBR-UHFFFAOYSA-L

InChI=1S/C7H16N2O.C6H8O4.Pt/c8-5-7(6-9)1-3-10-4-2-7;7-4(8)6(5(9)10)2-1-3-6;/h1-6,8-9H2;1-3H2,(H,7,8)(H,9,10);/q;;+2/p-2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2620257 | https://adisinsight.springer.com/drugs/800002455

Enloplatin (CL 287110) is a platinum complex with antineoplastic properties. It is more water soluble than cisplatin. Enloplatin was developing by Wyeth-Lederle for the treatment of patients with ovarian cancer and leukemia.

Originator

Approval Year

PubMed

Title	Date	PubMed
CL 287,110 and CL 286,558.	1989	2620257
Relationship of cellular glutathione to the cytotoxicity and resistance of seven platinum compounds.	1992 Dec 15	1458477
A phase II and pharmacokinetic study of enloplatin in patients with platinum refractory advanced ovarian carcinoma.	1997 Aug	9311439

Sample Use Guides

In Vivo Use Guide

Phase I trial: 83-375mg/m2

Route of Administration: Intravenous

Name

Type

Language

ENLOPLATIN

Official Name

English

ENLOPLATIN [MART.]

Common Name

English

PLATINUM, (1,1-CYCLOBUTANEDICARBOXYLATO(2-))(TETRAHYDRO-4H-PYRAN-4,4-DIMETHANAMINE-N,N')-, (SP-4-2)-

Common Name

English

enloplatin [INN]

Common Name

English

cis-(1,1-Cyclobutanedicarboxylato)[tetrahydro-4H-pyran-4,4-bis(methylamine)]platinum

Common Name

English

CL-287110

Code

English

ENLOPLATIN [USAN]

Common Name

English

CL 287,110

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1450