ENLOPLATIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H16N2O.C6H6O4.Pt
Molecular Weight	481.408
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Pt++].NCC1(CN)CCOCC1.[O-]C(=O)C2(CCC2)C([O-])=O

InChI

InChIKey=ASQRQYODAQUVBR-UHFFFAOYSA-L

InChI=1S/C7H16N2O.C6H8O4.Pt/c8-5-7(6-9)1-3-10-4-2-7;7-4(8)6(5(9)10)2-1-3-6;/h1-6,8-9H2;1-3H2,(H,7,8)(H,9,10);/q;;+2/p-2

HIDE SMILES / InChI

Molecular Formula	C7H16N2O
Molecular Weight	144.2147
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H6O4
Molecular Weight	142.1094
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Pt
Molecular Weight	195.084
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2620257 | https://adisinsight.springer.com/drugs/800002455

Enloplatin (CL 287110) is a platinum complex with antineoplastic properties. It is more water soluble than cisplatin. Enloplatin was developing by Wyeth-Lederle for the treatment of patients with ovarian cancer and leukemia.

Originator

Approval Year

PubMed

Title	Date	PubMed
CL 287,110 and CL 286,558.	1989	2620257
A phase II and pharmacokinetic study of enloplatin in patients with platinum refractory advanced ovarian carcinoma.	1997 Aug	9311439

Sample Use Guides

In Vivo Use Guide

Phase I trial: 83-375mg/m2

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:51:03 GMT 2023` Edited by `admin` on `Sat Dec 16 17:51:03 GMT 2023`
Record UNII	C7HT2IO79H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ENLOPLATIN

Official Name

English

ENLOPLATIN [MART.]

Common Name

English

PLATINUM, (1,1-CYCLOBUTANEDICARBOXYLATO(2-))(TETRAHYDRO-4H-PYRAN-4,4-DIMETHANAMINE-N,N')-, (SP-4-2)-

Common Name

English

enloplatin [INN]

Common Name

English

cis-(1,1-Cyclobutanedicarboxylato)[tetrahydro-4H-pyran-4,4-bis(methylamine)]platinum

Common Name

English

CL-287110

Code

English

ENLOPLATIN [USAN]

Common Name

English

CL 287,110

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C1450