U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry UNKNOWN
Molecular Formula C20H27FN2O3
Molecular Weight 362.4384
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CICARPERONE

SMILES

NC(=O)OC1CCN(CCCC(=O)C2=CC=C(F)C=C2)C3CCCCC13

InChI

InChIKey=RVPQELWEPXXXPC-UHFFFAOYSA-N
InChI=1S/C20H27FN2O3/c21-15-9-7-14(8-10-15)18(24)6-3-12-23-13-11-19(26-20(22)25)16-4-1-2-5-17(16)23/h7-10,16-17,19H,1-6,11-13H2,(H2,22,25)

HIDE SMILES / InChI
Cicarperone is decahydroquinoline derivative with local anesthetic action. In ex vivo models Cicarperone protected anesthetized guinea-pigs against ouabain-induced ventricular fibrillation and increased the lethal dose of ouabain. Unlike most drugs with local anesthetic properties, Cicarperone did not depress contractions in isolated atria but increased them. Cicarperone reduces the spontaneous frequency, maximum follow frequency and conduction velocity of rabbit isolated atria. Cicarperone had no blocking action on the chronotropic or positive inotropic actions of isoprenaline on isolated atrial muscle. In vivo evaluation of Cicarperone in anesthetized dogs shows that Cicarperone caused small dose-related bradycardia and a large dose-related decrease in peripheral vascular resistance. Ciclactate has never been marketed in the US and EU.

Approval Year

PubMed

PubMed

TitleDatePubMed
[Preventive action of 4-carbamoyloxy-1-4-(4-fluorophenyl)-4-oxobutyl-decahydroquinoline (L-7810) in epinephrine shock in the dog].
1972
The effects on cardiac muscle and nerve of a fluorinated decahydroquinoline derivative, L7810, rapidly absorbed after oral administration.
1973 Jun
Patents
Name Type Language
CICARPERONE
INN  
INN  
Official Name English
cicarperone [INN]
Common Name English
4'-FLUORO-4-(OCTAHYDRO-4-HYDROXY-1(2H-QUINOLYL)BUTYROPHENONE CARBAMATE (ESTER)
Common Name English
Code System Code Type Description
INN
3255
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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NCI_THESAURUS
C171688
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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CAS
54063-29-5
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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MESH
C004566
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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EVMPD
SUB06231MIG
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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FDA UNII
C65T2BG75L
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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SMS_ID
100000081902
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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ChEMBL
CHEMBL2104545
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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EPA CompTox
DTXSID60866386
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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PUBCHEM
68709
Created by admin on Fri Dec 15 16:32:55 GMT 2023 , Edited by admin on Fri Dec 15 16:32:55 GMT 2023
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