QUADROSILAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H28O4Si4
Molecular Weight	420.7545
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si]1(C)O[Si@](C)(O[Si](C)(C)O[Si@](C)(O1)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=ZTQZMPQJXABFNC-WMPKNSHKSA-N

InChI=1S/C18H28O4Si4/c1-23(2)19-25(5,17-13-9-7-10-14-17)21-24(3,4)22-26(6,20-23)18-15-11-8-12-16-18/h7-16H,1-6H3/t25-,26+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5022337 | https://www.ncbi.nlm.nih.gov/pubmed/1080332 | https://www.ncbi.nlm.nih.gov/pubmed/1080338

Quadrosilan is is a synthetic nonsteroidal estrogen that was developed in the 1970s and that is or has been used as an antigonadotropic agent in the treatment of prostate cancer. It is an organosilicon compound and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane. Quadrosilan has estrogenic activity equivalent to that of estradiol and can produce feminization and gynecomastia as side effects in male patients.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of oral 2,6-cis-diphenylhexamethylcyclotetrasiloxane on the reproductive system of the male rat.	1972-01	5022337

Patents

Name

Type

Language

CYCLOTETRASILOXANE, 2,2,4,6,6,8-HEXAMETHYL-4,8-DIPHENYL-, CIS-

Preferred Name

English

QUADROSILAN

Official Name

English

CIS-2,2,4,6,6,8-HEXAMETHYL-4,8-DIPHENYLCYCLOTETRASILOXANE

Common Name

English

quadrosilan [INN]

Common Name

English

2,2,4,6,6,8-HEXAMETHYL-4,8-DIPHENYLCYCLOTETRASILOXANE, CIS-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C242