QUADROSILAN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H28O4Si4
Molecular Weight	420.7545
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si]1(C)O[Si@](C)(O[Si](C)(C)O[Si@](C)(O1)C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=ZTQZMPQJXABFNC-WMPKNSHKSA-N

InChI=1S/C18H28O4Si4/c1-23(2)19-25(5,17-13-9-7-10-14-17)21-24(3,4)22-26(6,20-23)18-15-11-8-12-16-18/h7-16H,1-6H3/t25-,26+

HIDE SMILES / InChI

Molecular Formula	C18H28O4Si4
Molecular Weight	420.7545
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5022337 | https://www.ncbi.nlm.nih.gov/pubmed/1080332 | https://www.ncbi.nlm.nih.gov/pubmed/1080338

Quadrosilan is is a synthetic nonsteroidal estrogen that was developed in the 1970s and that is or has been used as an antigonadotropic agent in the treatment of prostate cancer. It is an organosilicon compound and is also known as 2,6-cisdiphenylhexamethylcyclotetrasiloxane. Quadrosilan has estrogenic activity equivalent to that of estradiol and can produce feminization and gynecomastia as side effects in male patients.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of oral 2,6-cis-diphenylhexamethylcyclotetrasiloxane on the reproductive system of the male rat.	1972-01	5022337

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:28:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:28:58 GMT 2025`
Record UNII	C5KT601WPM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CYCLOTETRASILOXANE, 2,2,4,6,6,8-HEXAMETHYL-4,8-DIPHENYL-, CIS-

Preferred Name

English

QUADROSILAN

Official Name

English

CIS-2,2,4,6,6,8-HEXAMETHYL-4,8-DIPHENYLCYCLOTETRASILOXANE

Common Name

English

quadrosilan [INN]

Common Name

English

2,2,4,6,6,8-HEXAMETHYL-4,8-DIPHENYLCYCLOTETRASILOXANE, CIS-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C242