U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C15H22N2O2.CH4O3S
Molecular Weight 358.453
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DABELOTINE MESYLATE, (R)-

SMILES

CS(O)(=O)=O.CN1CCCC2=C1C(OC[C@H]3CNCCO3)=CC=C2

InChI

InChIKey=RSEKRLGWBUABQM-BTQNPOSSSA-N
InChI=1S/C15H22N2O2.CH4O3S/c1-17-8-3-5-12-4-2-6-14(15(12)17)19-11-13-10-16-7-9-18-13;1-5(2,3)4/h2,4,6,13,16H,3,5,7-11H2,1H3;1H3,(H,2,3,4)/t13-;/m1./s1

HIDE SMILES / InChI
Dabelotine is a cognitive-enhancing drug, developed by Servier. The drug has been shown to improve some aspects of cognitive processes, such as attention, curiosity, motivation, acquisition, and recall of memory. Dabelotine has also been shown to reduce the effect of an anticholinergic drug such as scopolamine. The drug increases the in vitro K+-induced norepinephrine release in rodent cerebral slices, and have no effect on noradrenergic and cholinergic receptor binding sites. Dabelotine was investigated in phase 2 clinical trials for the treatment of dementia, where it was demonstrated that 50-mg and 100-mg doses produced an improvement in reaction time and performance in memory tasks.

Approval Year

Patents
Name Type Language
DABELOTINE MESYLATE, (R)-
Common Name English
(-)-(R)-S-12024
Code English
DABELOTINE MESILATE, (R)-
Common Name English
QUINOLINE, 1,2,3,4-TETRAHYDRO-1-METHYL-8-((2S)-2-MORPHOLINYLMETHOXY)-, MONOMETHANESULFONATE, (R)-
Systematic Name English
Code System Code Type Description
FDA UNII
C4PY3K6A28
Created by admin on Sat Dec 16 11:18:36 GMT 2023 , Edited by admin on Sat Dec 16 11:18:36 GMT 2023
PRIMARY
PUBCHEM
91827145
Created by admin on Sat Dec 16 11:18:36 GMT 2023 , Edited by admin on Sat Dec 16 11:18:36 GMT 2023
PRIMARY