Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C15H22N2O2.CH4O3S |
Molecular Weight | 358.453 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.CN1CCCC2=C1C(OC[C@H]3CNCCO3)=CC=C2
InChI
InChIKey=RSEKRLGWBUABQM-BTQNPOSSSA-N
InChI=1S/C15H22N2O2.CH4O3S/c1-17-8-3-5-12-4-2-6-14(15(12)17)19-11-13-10-16-7-9-18-13;1-5(2,3)4/h2,4,6,13,16H,3,5,7-11H2,1H3;1H3,(H,2,3,4)/t13-;/m1./s1
Dabelotine is a cognitive-enhancing drug, developed by Servier. The drug has been shown to improve some aspects of cognitive processes, such as attention, curiosity, motivation, acquisition, and recall of memory. Dabelotine has also been shown to reduce the effect of an anticholinergic drug such as scopolamine. The drug increases the in vitro K+-induced norepinephrine release in rodent cerebral slices, and have no effect on noradrenergic and cholinergic receptor binding sites. Dabelotine was investigated in phase 2 clinical trials for the treatment of dementia, where it was demonstrated that 50-mg and 100-mg doses produced an improvement in reaction time and performance in memory tasks.
CNS Activity
Approval Year
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C4PY3K6A28
Created by
admin on Sat Dec 16 11:18:36 GMT 2023 , Edited by admin on Sat Dec 16 11:18:36 GMT 2023
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91827145
Created by
admin on Sat Dec 16 11:18:36 GMT 2023 , Edited by admin on Sat Dec 16 11:18:36 GMT 2023
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PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD