Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H16N2O |
| Molecular Weight | 240.3003 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC(=CC(C)=C1)C(=O)NCC2=CC=NC=C2
InChI
InChIKey=JROSDBYIFZWPBP-UHFFFAOYSA-N
InChI=1S/C15H16N2O/c1-11-7-12(2)9-14(8-11)15(18)17-10-13-3-5-16-6-4-13/h3-9H,10H2,1-2H3,(H,17,18)
Picobenzide is a synthetic product which is of therapeutic interest owing to its neuroleptic, anti-inflammatory and spasmolytic action and because its properties are similar to those of the phenotiazines. The product is largely metabolized into the N-oxide form and is also partially eliminated in urine in an unaltered state.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Comparative study of the pharmacological activity of N-(4-picolyl)-3,5-dimethylbenzamide (M-14012-4) and its N-oxide metabolite (M-3312-4). New pharmacological aspects]. | 1979 Dec |
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| [Effect of N-(4-picolyl)-3,5 dimethylbenzamide on arterial pressure and heart rate in unanesthetized rats]. | 1981 Apr |
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| [Effect of N-(4-picolyl)-3,5 dimethylbenzamide (M-14012-4) on stereotyped behavior induced by apomorphine and amphetamine in the rat and mouse]. | 1981 Apr |
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| [Modification of the triphasic mortality curve of d-amphetamine]. | 1982 Dec |
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| [Comparative study of the central effects of M-14012-A and SKF-525-A in rodents]. | 1983 Aug |
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| Determination of N-oxide of picobenzide by differential pulse polarography. | 1983 Oct |
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| [Effect of MA-14012 (Dosetil) on lymphocyte mitogenesis. In vitro study]. | 1984 Jan-Feb |
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| A dopaminergic receptor modulates catecholamine release from the cat adrenal gland. | 1985 May |
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| Pharmacokinetics and initial distribution of a new neuroleptic agent picobenzide (M-14012-4). | 1985 May |
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| 'In vitro' metabolism of N-picolyl-3,5-dimethylbenzamides. | 1986 Apr-Jun |
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| Isolation and identification of the N-oxide metabolite of picobenzide in human urine. | 1986 Jan-Mar |
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| Study of the disposition kinetics of the N-oxide-derivative: a metabolite of picobenzide. | 1989 Jan-Mar |
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| Synthesis and biological activity of picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) analogues as potential antipsychotic agents. | 2005 |
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NCI_THESAURUS |
C29710
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C016938
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40146
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100000081919
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CHEMBL1581974
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C76443
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4674
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DTXSID10199792
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SUB09814MIG
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C46317G8F0
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51832-87-2
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ACTIVE MOIETY
