Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2ClO4.Ni |
| Molecular Weight | 257.595 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Ni++].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O
InChI
InChIKey=ZLQBNKOPBDZKDP-UHFFFAOYSA-L
InChI=1S/2ClHO4.Ni/c2*2-1(3,4)5;/h2*(H,2,3,4,5);/q;;+2/p-2
DescriptionSources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Sources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Nickel(II) chloride (NiCl2), a water soluble salt of Nickel, is a toxic and carcinogenic environmental and occupational pollutant, which has been shown to be carcinogenic to the lungs and nasal passages, in cases of long-term inhalation exposure. It was approved that NiCl2 was a potential genotoxicity caused indirect DNA damage by the production of ROS. In addition was conducted studies to evaluate the precise mechanism of Ni toxicology. And it was shown, thet NiCl2 induced and caused cell cycle G2/M phase arrest via p53-dependent pathway and generated inflammatory response by NF-κB pathway activation.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: map04064 |
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Target ID: GO:0044839 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | ECZEMOL Approved UseEczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies. |
|||
PubMed
| Title | Date | PubMed |
|---|---|---|
| NAS-benzidine reaction of blood cells-new simple peroxidase staining method using nickel-ammonium sulfate. | 1951 Aug |
|
| THE EFFECT OF PHYSICAL FORM OF IMPLANT ON NICKEL SULPHIDE TUMOURIGENESIS IN THE RAT. | 1963 |
|
| Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates. | 1983 |
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| Nickel oxide: potential carcinogenicity--a review and further evidence. | 1984 |
|
| Occupational asthma from nickel sensitivity: II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity. | 1984 Feb |
|
| Pulmonary deposition and clearance of a nickel oxide aerosol by inhalation. | 1985 Feb |
|
| Carcinogenesis bioassays of nickel oxides and nickel-copper oxides by intramuscular administration to Fischer-344 rats. | 1990 Oct |
|
| Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease. | 1991 |
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| Risk assessment of nickel carcinogenicity and occupational lung cancer. | 1994 Jan |
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| Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. | 1996 Sep |
|
| How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? | 1996 Sep |
|
| Daily intake of essential minerals and metallic micropollutants from foods in France. | 1998 Jun 30 |
|
| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
|
| Effect of nickel and iron co-exposure on human lung cells. | 2004 Apr 15 |
|
| Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds. | 2004 Jan |
|
| Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
|
| Interactions of a pesticide/heavy metal mixture in marine bivalves: a transcriptomic assessment. | 2011 Apr 16 |
|
| A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice. | 2011 Apr 22 |
|
| Nickel differentially regulates NFAT and NF-κB activation in T cell signaling. | 2011 Aug 1 |
|
| An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. | 2011 Dec |
|
| Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells. | 2011 Dec 9 |
|
| Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling. | 2011 Jul 11 |
|
| Nickel-induced down-regulation of ΔNp63 and its role in the proliferation of keratinocytes. | 2011 Jun 15 |
|
| Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin. | 2011 Nov |
|
| Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death. | 2011 Nov 18 |
|
| Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. | 2012 Jul |
|
| Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. | 2012 Jul 20 |
|
| Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma. | 2013 |
|
| GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression. | 2013 |
|
| Crucial role of Toll-like receptors in the zinc/nickel-induced inflammatory response in vascular endothelial cells. | 2013 Dec 15 |
|
| Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators. | 2013 Jun |
|
| p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. | 2013 Jun 15 |
|
| Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure. | 2013 Mar |
|
| Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells. | 2013 Mar |
|
| The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment. | 2013 May |
|
| Dietary nickel chloride restrains the development of small intestine in broilers. | 2013 Nov |
|
| Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. | 2013 Sep |
|
| Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice. | 2013 Sep |
|
| Cobalt and nickel stabilize stem cell transcription factor OCT4 through modulating its sumoylation and ubiquitination. | 2014 |
|
| Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. | 2014 Apr |
|
| Nickel induces interleukin-1β secretion via the NLRP3-ASC-caspase-1 pathway. | 2014 Apr |
|
| MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. | 2014 Feb 27 |
|
| Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers. | 2014 Jan |
|
| Genotoxic changes to rodent cells exposed in vitro to tungsten, nickel, cobalt and iron. | 2014 Mar 10 |
|
| The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1). | 2014 Sep 15 |
|
| Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells. | 2015 Jan 2 |
|
| Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury). | 2015 Mar |
|
| Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans. | 2016 Aug |
|
| Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression. | 2016 Jan |
|
| The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells. | 2016 Jul |
Patents
Sample Use Guides
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration:
Oral
The effect of 44 different metal salts on the activity of the reverse transcriptase
(RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.
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ACTIVE MOIETY
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
