Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H6ClNO |
| Molecular Weight | 179.603 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C(Cl)C2=C1N=CC=C2
InChI
InChIKey=CTQMJYWDVABFRZ-UHFFFAOYSA-N
InChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5,12H
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24513205
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/24513205
Cloxyquin has being shown to be a novel activator of the two-pore domain
potassium channel TRESK, which is linked to causing migraines and controls the sensitivity of pain nerves in the brain.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: UNIPROT: Q208C2 (Acyl-CoA-binding protein) |
0.097 µM [IC50] | ||
Target ID: CHEMBL360 |
|||
Target ID: CHEMBL2331042 |
3.8 µM [EC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
|||
| Primary | Unknown Approved UseUnknown |
|||
| Preventing | Unknown Approved UseUnknown |
Doses
| Dose | Population | Adverse events |
|---|---|---|
5 % multiple, topical Studied dose |
unhealthy, 68 years n = 1 Health Status: unhealthy Condition: cutaneous mycosis Age Group: 68 years Sex: F Population Size: 1 Sources: |
Other AEs: Contact dermatitis... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Contact dermatitis | 5 % multiple, topical Studied dose |
unhealthy, 68 years n = 1 Health Status: unhealthy Condition: cutaneous mycosis Age Group: 68 years Sex: F Population Size: 1 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes. | 2006 Mar 15 |
|
| In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis. | 2007 Mar |
|
| Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands. | 2007 Nov 1 |
|
| Outlook on Thailand's genomics and computational biology research and development. | 2008 Jul 25 |
|
| Bis(μ-5-chloro-quinolin-8-olato)-κN,O:O;κO:N,O-bis-[(acetato-κO,O')lead(II)]. | 2009 Feb 11 |
|
| 5-Chloro-8-hydroxy-quinolinium nitrate. | 2009 May 29 |
|
| Grafting aluminum(III) 8-hydroxyquinoline derivatives on MCM-41 mesoporous silica for tuning of the light emitting color. | 2010 Jun 15 |
|
| Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction. | 2013 Mar 28 |
Patents
Sample Use Guides
In Vitro Use Guide
Curator's Comment: Growth of the organisms was determined after reincubation at 37°C for 16 to 24 h by visual determination of a color change from blue to pink. The MIC was defined as the lowest concentration which prevented the color change.
The MICs of cloxyquin for 150 clinical isolates of Mycobacterium tuberculosis ranged from 0.062 to 0.25 g/ml. The MIC50 and MIC90 were 0.125 and 0.25 g/ml, respectively.
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
NCI_THESAURUS |
C254
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID4045973
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
BPF36H1G6S
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
204-978-1
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
C61689
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
CHEMBL225164
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
100000084038
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
3428
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
130-16-5
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
SUB06784MIG
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
3114
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
2817
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | |||
|
m3675
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY | Merck Index | ||
|
35083
Created by
admin on Fri Dec 15 15:15:26 GMT 2023 , Edited by admin on Fri Dec 15 15:15:26 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
