Details
| Stereochemistry | EPIMERIC |
| Molecular Formula | C16H21NO3.BrH |
| Molecular Weight | 356.255 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Br.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3
InChI
InChIKey=DWSGTFTVBLXELC-RDYJJYPNSA-N
InChI=1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H/t12-,13+,14+,15?;
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Palliative | HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE Approved UseHydrocodone bitartrate and homatropine methylbromide syrup is indicated for the symptomatic relief of cough. Launch Date1983 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Anticholinergic delirium caused by topical homatropine ophthalmologic solution: confirmation by anticholinergic radioreceptor assay in two cases. | 1992 Spring |
|
| Buspirone, but not sumatriptan, induces miosis in humans: relevance for a serotoninergic pupil control. | 1995 Mar |
|
| Herpes simplex virus type 1 associated acute retinal necrosis following encephalitis. | 2001 |
|
| Tris(2,2'-bipyridine)ruthenium(II) electrogenerated chemiluminescence of alkaloid type drugs with solid phase extraction sample preparation. | 2001 Jan |
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| Scavenging of photogenerated oxidative species by antimuscarinic drugs: atropine and derivatives. | 2002 |
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| Human carboxylesterase 1: from drug metabolism to drug discovery. | 2003 Jun |
|
| Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. | 2003 May |
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| Corneal topographic changes following retinal surgery. | 2004 Aug 3 |
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| Familial HLA-A2- and HLA-B7-associated anterior uveitis. | 2004 Oct |
|
| Acute posterior multifocal placoid pigment epitheliopathy after meningococcal C conjugate vaccine. | 2005 Apr |
|
| Frontotemporal dementia with co-occurrence of astrocytic plaques and tufted astrocytes, and severe degeneration of the cerebral white matter: a variant of corticobasal degeneration? | 2005 Mar |
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| Evaluation of amniotic membrane transplantation as an adjunct to medical therapy as compared with medical therapy alone in acute ocular burns. | 2005 Nov |
|
| Homatropine and psychosis in Weill-Marchesani syndrome. | 2006 Jul |
|
| Increasing the scale of true moving bed electrophoretic separations using filtration to reduce solvent volumetric flows between sections II and III. | 2007 Jan 5 |
|
| Capillary electrophoresis of tropane alkaloids and glycoalkaloids occurring in Solanaceae plants. | 2008 |
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| Granuloma annulare anterior uveitis. | 2008 Jan-Feb |
|
| Hypotony maculopathy in a patient with HLA-B27-associated uveitis. | 2008 May-Jun |
|
| Voriconazole for the treatment of refractory Aspergillus fumigatus keratitis. | 2008 May-Jun |
|
| Keratouveitis caused by Euphorbia plant sap. | 2009 Jul-Aug |
|
| Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
|
| Tubulointerstitial nephritis with uveitis syndrome: A case report and review of literature. | 2010 Apr |
|
| Is homatropine 5% effective in reducing pain associated with corneal abrasion when compared with placebo? A randomized controlled trial. | 2010 Dec |
|
| Current approach in the diagnosis and management of panuveitis. | 2010 Jan-Feb |
|
| Inhibitory effect of anticholinergics on the contraction of isolated caprine urinary bladder detrusor muscle. | 2010 Jul |
|
| Acute postoperative endophthalmitis by Gemella haemolysans. | 2010 May-Jun |
|
| Refractive error and visual functions in children with special needs compared with the first grade school students in oman. | 2010 Oct |
|
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
Sample Use Guides
Adults and Adolescents 12 Years of Age and Older: 1 tablet or 5 mL (1 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 6 tablets or 30 mL (6 teaspoonfuls) in 24 hours. Children 6 to 11 Years of Age: 1/2 tablet or 2.5 mL (1/2 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 3 tablets or 15 mL (3 teaspoonfuls) in 24 hours.
Route of Administration:
Oral
Isolated caprine urinary bladder detrusor muscle strips were incubated with homatropine at 5 uM after being contracted with 100 mum acetylcholine. The drug inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh.
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NCI_THESAURUS |
C29704
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NCI_THESAURUS |
C29706
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235428
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DTXSID5045099
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100000078129
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757047
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51-56-9
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m6038
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CHEMBL1618018
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BEW7469QZ0
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SUB14111MIG
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DBSALT001537
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1310008
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HOMATROPINE HYDROBROMIDE
Created by
admin on Fri Dec 15 15:12:04 GMT 2023 , Edited by admin on Fri Dec 15 15:12:04 GMT 2023
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PRIMARY | Description: Colourless crystals or a white, crystalline powder; odourless. Solubility: Freely soluble in water; sparingly soluble in ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Mydriatic. Storage: Homatropine hydrobromide should be kept in a tightly closed container, protected from light.Definition: Homatropine hydrobromide contains not less than 98.5% and not more than 101.0% of C16H21NO3,HBr, calculated with reference to the dried substance. | ||
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BEW7469QZ0
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C29093
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200-105-3
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ACTIVE MOIETY
SUBSTANCE RECORD
