SALAZOSULFAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H11N3O5S
Molecular Weight	321.309
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NS(=O)(=O)C1=CC=C(C=C1)\N=N\C2=CC(C(O)=O)=C(O)C=C2

InChI

InChIKey=NBSRUZQXRUNPNY-FOCLMDBBSA-N

InChI=1S/C13H11N3O5S/c14-22(20,21)10-4-1-8(2-5-10)15-16-9-3-6-12(17)11(7-9)13(18)19/h1-7,17H,(H,18,19)(H2,14,20,21)/b16-15+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28912853

Salazosulfamide was studied for the treatment of ankylosing spondylitis. It was found that salazosulfamide efficacy is associated with N-acetyltransferase 1 polymorphisms and in particularly, NAT1 AA/GG genotype at 263 locus. However, future studies should be conducted to investigate these issues.

Approval Year

PubMed

Title	Date	PubMed
Efficacy research of salazosulfamide in ankylosing spondylitis and NAT1 gene polymorphism.	2017-10	28912853
NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis.	2010-10	20180012
[Observation on therapeutic effect of heat needle combined with herb iontophoresis and western medicine on rheumatoid arthritis].	2007-10	18257347
Enhancement of reductive metabolism of p-nitrobenzoate and nitrazepam in isolated perfused rat liver by ethanol.	1979-05-01	38090

Sample Use Guides

In Vivo Use Guide

The experimental group received 7.5 mg of salazosulfamide (MTX) per week

Route of Administration: Oral

Name

Type

Language

NSC-27236

Preferred Name

English

SALAZOSULFAMIDE

Official Name

English

salazosulfamide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29739