CILADOPA HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H26N2O4.ClH
Molecular Weight	406.903
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=C(OC)C=C(C=C1)[C@H](O)CN2CCN(CC2)C3=CC=CC=CC3=O

InChI

InChIKey=UIOUCVPFPQUSAS-FSRHSHDFSA-N

InChI=1S/C21H26N2O4.ClH/c1-26-20-9-8-16(14-21(20)27-2)19(25)15-22-10-12-23(13-11-22)17-6-4-3-5-7-18(17)24;/h3-9,14,19,25H,10-13,15H2,1-2H3;1H/t19-;/m1./s1

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3336454 | https://www.ncbi.nlm.nih.gov/pubmed/3435077 | https://www.ncbi.nlm.nih.gov/pubmed/3606037 | https://www.ncbi.nlm.nih.gov/pubmed/3574692

Ciladopa, is a troponylpiperazine derivative and dopamine agonist that has been shown to influence dopaminergic mechanisms in animals. Preclinical pharmacological studies have suggested that it has antiparkinsonian activity similar to that of bromocriptine but without many of the troublesome side effects. Unfortunately in some clinical trials no significant differences was found among the treatment groups and placebo.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
D(2) dopamine receptor 58 Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3774130	Agonist 2678

PubMed

Title	Date	PubMed
More on ciladopa.	1987 Oct	3435077

Patents

Sample Use Guides

In Vivo Use Guide

15 mg twice daily for 8 weeks

Route of Administration: Oral

Name

Type

Language

CILADOPA HYDROCHLORIDE

Official Name

English

TREMERASE

Brand Name

English

(-)-(S)-2-(4-(.BETA.-HYDROXY-3,4-DIMETHOXYPHENETHYL)-1-PIPERAZINYL)-2,4,6-CYCLOHEPTATRIEN-1-ONE MONOHYDROCHLORIDE

Systematic Name

English

AY-27,110

Code

English

2,4,6-CYCLOHEPTATRIEN-1-ONE, 2-(4-(2-(3,4-DIMETHOXYPHENYL)-2-HYDROXYETHYL)-1-PIPERAZINYL)-, MONOHYDROCHLORIDE, (S)-

Systematic Name

English

CILADOPA HYDROCHLORIDE [USAN]

Common Name

English

AY-27110

Code

English

CILADOPA HYDROCHLORIDE [MART.]

Common Name

English

CILADOPA HCL

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL2110793