CILADOPA HYDROCHLORIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H26N2O4.ClH
Molecular Weight	406.903
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1=C(OC)C=C(C=C1)[C@H](O)CN2CCN(CC2)C3=CC=CC=CC3=O

InChI

InChIKey=UIOUCVPFPQUSAS-FSRHSHDFSA-N

InChI=1S/C21H26N2O4.ClH/c1-26-20-9-8-16(14-21(20)27-2)19(25)15-22-10-12-23(13-11-22)17-6-4-3-5-7-18(17)24;/h3-9,14,19,25H,10-13,15H2,1-2H3;1H/t19-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H26N2O4
Molecular Weight	370.4421
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3336454 | https://www.ncbi.nlm.nih.gov/pubmed/3435077 | https://www.ncbi.nlm.nih.gov/pubmed/3606037 | https://www.ncbi.nlm.nih.gov/pubmed/3574692

Ciladopa, is a troponylpiperazine derivative and dopamine agonist that has been shown to influence dopaminergic mechanisms in animals. Preclinical pharmacological studies have suggested that it has antiparkinsonian activity similar to that of bromocriptine but without many of the troublesome side effects. Unfortunately in some clinical trials no significant differences was found among the treatment groups and placebo.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
D(2) dopamine receptor 58 Target ID: P14416 Gene ID: 1813.0 Gene Symbol: DRD2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/3774130	Agonist 2678

PubMed

Title	Date	PubMed
More on ciladopa.	1987 Oct	3435077

Patents

Sample Use Guides

In Vivo Use Guide

15 mg twice daily for 8 weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:03 GMT 2023` Edited by `admin` on `Fri Dec 15 15:32:03 GMT 2023`
Record UNII	ASR1NR721I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CILADOPA HYDROCHLORIDE

Official Name

English

TREMERASE

Brand Name

English

(-)-(S)-2-(4-(.BETA.-HYDROXY-3,4-DIMETHOXYPHENETHYL)-1-PIPERAZINYL)-2,4,6-CYCLOHEPTATRIEN-1-ONE MONOHYDROCHLORIDE

Systematic Name

English

AY-27,110

Code

English

2,4,6-CYCLOHEPTATRIEN-1-ONE, 2-(4-(2-(3,4-DIMETHOXYPHENYL)-2-HYDROXYETHYL)-1-PIPERAZINYL)-, MONOHYDROCHLORIDE, (S)-

Systematic Name

English

CILADOPA HYDROCHLORIDE [USAN]

Common Name

English

AY-27110

Code

English

CILADOPA HYDROCHLORIDE [MART.]

Common Name

English

CILADOPA HCL

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL2110793