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Details

Stereochemistry ABSOLUTE
Molecular Formula C5H11NO2S.ClH
Molecular Weight 185.672
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETHYL CYSTEINATE HYDROCHLORIDE

SMILES

Cl.CCOC(=O)[C@@H](N)CS

InChI

InChIKey=JFKJWWJOCJHMGV-WCCKRBBISA-N
InChI=1S/C5H11NO2S.ClH/c1-2-8-5(7)4(6)3-9;/h4,9H,2-3,6H2,1H3;1H/t4-;/m0./s1

HIDE SMILES / InChI

Description
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/ethyl-l-cysteine-hydrochloride.html | https://www.ncbi.nlm.nih.gov/pubmed/16309906 | https://www.ncbi.nlm.nih.gov/pubmed/15203134

Ethyl cysteinate is derivative of semi-essential proteinogenic amino acid Cysteine. Ethyl cysteinate is widely used in food additive, cosmetic, pharmaceutical area. Ethyl cysteinate is membrane-permeable, readily enters peripheral tissues and the brain, and increases intracellular pools of cysteine in these tissues via a membrane-associated carboxylesterase. The increased availability of cysteine directly alters the redox status of cells and enhances glutathione production. The enhanced biovailability of L-cysteine and L-glutathione would also promote the direct formation of the S-nitrosothiols, L-S-nitrosocysteine and L-S-nitrosoglutathione and the overall S-nitrosylation status of functional proteins in cells.

Originator

Sources: Experientia, Volume2, Pages 411-12, Journal, 1946

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: membrane-associated carboxylesterase
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
(99m)Tc-ethyl cysteinate dimer brain SPECT findings in early stage of dementia with Lewy bodies and Parkinson's disease patients: a correlation with neuropsychological tests.
2008-01
Patents

Patents

Sample Use Guides

The antiinflammatory activity of Ethyl cysteinate was assessed from it’s ability to inhibit the paw edema induced by carrageenan in Balb/C mice. The Ethyl cysteinate were administered ip at a dose of 150 lmol/kg and demonstrated a significant inhibition of the edema. The gastrointestinal toxicity profile of Ethyl cysteinate (84 mkM/kg) was evaluated in vivo following a 4-day oral dosage scheme in rats.
Route of Administration: Other
Ethyl cysteinate activity was evaluated in lipid peroxidation assay. The supernatant fraction hepatic microsomal membrane lipids. Lipid peroxidation was assessed by the formation of thiobarbituric acid (TBA)-reactive substances (e.g. malondialdehyde). Cysteine ethyl ester (1 uM) inhibited lipid peroxidation by 49%.
Name Type Language
ETHYL CYSTEINATE HYDROCHLORIDE
Systematic Name English
ETHYL L-CYSTEINE HYDROCHLORIDE
JAN  
Preferred Name English
L-CYSTEINE, ETHYL ESTER, HYDROCHLORIDE
Common Name English
L-CYSTEINE ETHYL ESTER, HYDROCHLORIDE
WHO-DD  
Systematic Name English
ETHYL CYSTEINE HYDROCHLORIDE
Systematic Name English
L-CYSTEINE ETHYLESTER HYDROCHLORIDE
Systematic Name English
ETHYL L-CYSTEINE HYDROCHLORIDE [JAN]
Common Name English
CYSTEINE, ETHYL ESTER, HYDROCHLORIDE, L-
Common Name English
NSC-117387
Code English
L-cysteine ethyl ester, hydrochloride [WHO-DD]
Common Name English
ETHYL L-2-AMINO-3-MERCAPTOPROPIONATE HYDROCHLORIDE
Common Name English
CYSTANIN
Brand Name English
L-CYSTEINE, ETHYL ESTER, HYDROCHLORIDE (1:1)
Common Name English
ETHYL L-CYSTEINATE HYDROCHLORIDE
Systematic Name English
Code System Code Type Description
EVMPD
SUB14334MIG
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
PRIMARY
ChEMBL
CHEMBL863
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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ECHA (EC/EINECS)
212-779-6
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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PUBCHEM
13358
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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SMS_ID
100000077082
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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EPA CompTox
DTXSID4046527
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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NSC
117387
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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FDA UNII
AM467TB2I1
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
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RXCUI
236634
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
PRIMARY RxNorm
CAS
868-59-7
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
PRIMARY
EVMPD
SUB21813
Created by admin on Mon Mar 31 19:58:13 GMT 2025 , Edited by admin on Mon Mar 31 19:58:13 GMT 2025
PRIMARY