U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C25H33ClN2O4
Molecular Weight 460.994
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NISTERIME

SMILES

[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C\C(=N\OC5=CC=C(C=C5)[N+]([O-])=O)[C@H](Cl)C[C@]34C

InChI

InChIKey=FSSASQYIDSGHST-PROZPENESA-N
InChI=1S/C25H33ClN2O4/c1-24-12-11-20-18(19(24)9-10-23(24)29)8-3-15-13-22(21(26)14-25(15,20)2)27-32-17-6-4-16(5-7-17)28(30)31/h4-7,15,18-21,23,29H,3,8-14H2,1-2H3/b27-22-/t15-,18-,19-,20-,21+,23-,24-,25-/m0/s1

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA876#v=onepage&q&f=false

Nisterime is a dihydrotestosterone derivative. Nisterime acetate (ORF-9326) was shown to inhibit implantation in several species. It is also interrupts the postimplantation stage of gestation.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions
PubMed

PubMed

TitleDatePubMed
Disposition of ORF 9326, a novel contragestational steroid, in animals.
1978 Sep

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Name Type Language
NISTERIME
INN  
INN  
Official Name English
2.ALPHA.-CHLORO-17.BETA.-HYDROXY-5.ALPHA.-ANDROSTAN-3-ONE O-(P-NITROPHENYL)OXIME
Common Name English
nisterime [INN]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL2104712
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
CAS
51354-32-6
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
WIKIPEDIA
Nisterime
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
PUBCHEM
5361472
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
FDA UNII
ABF7S9U8W6
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
EPA CompTox
DTXSID201023661
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
NCI_THESAURUS
C174618
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
SMS_ID
100000083890
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
INN
4193
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY
EVMPD
SUB09309MIG
Created by admin on Fri Dec 15 19:08:47 GMT 2023 , Edited by admin on Fri Dec 15 19:08:47 GMT 2023
PRIMARY