NISTERIME

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H33ClN2O4
Molecular Weight	460.994
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])CC[C@@]4([H])C\C(=N\OC5=CC=C(C=C5)[N+]([O-])=O)[C@H](Cl)C[C@]34C

InChI

InChIKey=FSSASQYIDSGHST-PROZPENESA-N

InChI=1S/C25H33ClN2O4/c1-24-12-11-20-18(19(24)9-10-23(24)29)8-3-15-13-22(21(26)14-25(15,20)2)27-32-17-6-4-16(5-7-17)28(30)31/h4-7,15,18-21,23,29H,3,8-14H2,1-2H3/b27-22-/t15-,18-,19-,20-,21+,23-,24-,25-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C25H33ClN2O4
Molecular Weight	460.994
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=iknTBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false
Curator's Comment: Description was created based on several sources, including https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA876#v=onepage&q&f=false

Nisterime is a dihydrotestosterone derivative. Nisterime acetate (ORF-9326) was shown to inhibit implantation in several species. It is also interrupts the postimplantation stage of gestation.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Androgen Receptor 167 Target ID: CHEMBL1871 Sources: http://www.genome.jp/dbget-bin/www_bget?dr:D05174	Agonist 2678

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pregnancy 65 Sources: Glasser, S.R. & Bullock, D.W. (2012) Cellular and Molecular Aspects of Implantation, page 479, retrieved from: https://books.google.ru/books?id=iknTBwAAQBAJ	Preventing		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Disposition of ORF 9326, a novel contragestational steroid, in animals.	1978 Sep	102053

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:08:47 GMT 2023` Edited by `admin` on `Fri Dec 15 19:08:47 GMT 2023`
Record UNII	ABF7S9U8W6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NISTERIME

Official Name

English

2.ALPHA.-CHLORO-17.BETA.-HYDROXY-5.ALPHA.-ANDROSTAN-3-ONE O-(P-NITROPHENYL)OXIME

Common Name

English

nisterime [INN]

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL2104712