Details
Stereochemistry | ACHIRAL |
Molecular Formula | C17H15ClN4S |
Molecular Weight | 342.846 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=CC2=C(S1)N3C(C)=NN=C3CN=C2C4=C(Cl)C=CC=C4
InChI
InChIKey=VMZUTJCNQWMAGF-UHFFFAOYSA-N
InChI=1S/C17H15ClN4S/c1-3-11-8-13-16(12-6-4-5-7-14(12)18)19-9-15-21-20-10(2)22(15)17(13)23-11/h4-8H,3,9H2,1-2H3
DescriptionCurator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/25538342
Curator's Comment: description was created based on several sources, including, www.ncbi.nlm.nih.gov/pubmed/25538342
Etizolam is an analogue of benzodiazepine that contains thienotriazolodiazepine group. The drug was developed and approved in Japan and now is used in Japan, Italy and India for the treatment of anxiety disorders. Etizolam exerts its action through activation of GABA A receptors, moreover, the agonistic behavior was shown on isolated neurons. There are several cases when etizolam dependence was reported. In many countries the drug is recognized as a psychoactive substance and its distribution is illegal there.
Approval Year
PubMed
Title | Date | PubMed |
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Nightmares and panic disorder associated with carvedilol overdose. | 2002 Nov |
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[Practical analysis of toxic substances useful for clinical toxicology--10--benzodiazepine]. | 2004 Apr |
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Effect of platelet-activating factor receptor antagonist, etizolam, on resolution of chronic subdural hematoma--a prospective study to investigate use as conservative therapy. | 2005 Dec |
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Pharmacokinetic interactions between Japanese traditional Kampo medicine and modern medicine (IV). Effect of Kamisyoyosan and Tokisyakuyakusan on the pharmacokinetics of etizolam in rats. | 2005 Feb |
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Induction of the metabolism of etizolam by carbamazepine in humans. | 2005 May |
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Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs. | 2005 Sep |
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Low tolerance and dependence liabilities of etizolam: molecular, functional, and pharmacological correlates. | 2005 Sep 5 |
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Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. | 2006 Apr |
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Multi-center randomized control trial of etizolam plus NSAID combination for tension-type headache. | 2007 |
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Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. | 2007 Aug |
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Serotonin syndrome in a case of depression with various somatic symptoms: the difficulty in differential diagnosis. | 2007 Jan 30 |
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Accidental etizolam ingestion in a child. | 2007 Jul |
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Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam. | 2007 May |
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Absence status associated with focal activity and polydipsia-induced hyponatremia. | 2008 Apr |
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Benzodiazepine metabolism: an analytical perspective. | 2008 Oct |
Sample Use Guides
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/16107249
Exposure of rat hippocampal neurons in culture to 10 microM etizolam for 5 days reduced the amounts of alpha5 and gamma2S receptor subunit mRNAs.
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NCI_THESAURUS |
C1012
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WIKIPEDIA |
Designer-drugs-Etizolam
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WHO-ATC |
N05BA19
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WHO-VATC |
QN05BA19
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ETIZOLAM
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SUB07313MIG
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CHEMBL1289779
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100000082100
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C044610
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40054-69-1
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DTXSID0023030
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m5189
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A76XI0HL37
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1102
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4563
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3307
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C65583
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DB09166
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ACTIVE MOIETY
METABOLITE (PARENT)