Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C19H20FN5O4.C4H7NO4.H2O |
| Molecular Weight | 552.5096 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.N[C@H](CC(O)=O)C(O)=O.CO\N=C1/CN(CC12CNC2)C3=C(F)C=C4C(=O)C(=CN(C5CC5)C4=N3)C(O)=O
InChI
InChIKey=CKUBQLBJSAPAGK-WCRXHYIJSA-N
InChI=1S/C19H20FN5O4.C4H7NO4.H2O/c1-29-23-14-6-24(9-19(14)7-21-8-19)17-13(20)4-11-15(26)12(18(27)28)5-25(10-2-3-10)16(11)22-17;5-2(4(8)9)1-3(6)7;/h4-5,10,21H,2-3,6-9H2,1H3,(H,27,28);2H,1,5H2,(H,6,7)(H,8,9);1H2/b23-14+;;/t;2-;/m.1./s1
Zabofloxacin (also known as DW-224a), a fluoroquinolone antibiotic agent, is a dual inhibitor of both DNA gyrase and topoisomerase IV of Streptococcus pneumonia. Zabofloxacin successfully has completed phase III clinical trial in patients with acute bacterial exacerbation of the chronic obstructive pulmonary disease. In addition, in May 2012, IASO terminated phase II trial of oral zabofloxacin capsules in patients with moderate-to-severe community-acquired pneumonia due to financial considerations.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| New treatment options for lower respiratory tract infections. | 2017-09 |
|
| DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae. | 2010-07 |
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| Zabofloxacin (DW-224a) activity against Neisseria gonorrhoeae including quinolone-resistant strains. | 2008-09 |
|
| Safety pharmacology of DW-224a, a novel fluoroquinolone antibiotic agent. | 2004-11 |
Patents
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Preferred Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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A09UU5N4TW
Created by
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100000182643
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SUB196892
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131633976
Created by
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1808295-60-4
Created by
admin on Tue Apr 01 21:25:43 GMT 2025 , Edited by admin on Tue Apr 01 21:25:43 GMT 2025
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PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
