TIRACIZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H25N3O3
Molecular Weight	367.4415
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TIRACIZINE

Structure Search

SMILES

CCOC(=O)NC1=CC=C2CCC3=C(C=CC=C3)N(C(=O)CN(C)C)C2=C1

InChI

InChIKey=KJAMZCVTJDTESW-UHFFFAOYSA-N

InChI=1S/C21H25N3O3/c1-4-27-21(26)22-17-12-11-16-10-9-15-7-5-6-8-18(15)24(19(16)13-17)20(25)14-23(2)3/h5-8,11-13H,4,9-10,14H2,1-3H3,(H,22,26)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9412062 | https://www.ncbi.nlm.nih.gov/pubmed/8527691

Tiracizine a drug belongs to the new class I antiarrhythmic agent was studied in patients with ischemic heart disease, where was shown, that the drug could decrease myocardial contractile function.

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Correction of the cardiotoxic effect of the anti-arrhythmia agents with befol, sufan, and their combination].	1998-06	9693756
[The anti-arrhythmia action of tiracizine in patients with ischemic heart disease and decreased myocardial contractile function].	1997-06	9412062
Day-night variations in the renal excretion of the antiarrhythmic agent tiracizine and its metabolites.	1995-04	8653799
Use dependent depression of fast sodium current in heart muscle by the new antiarrhythmic substance Bonnecor (AWD 19-166, GS 015).	1985-12	2419929

Patents

Patents

Sample Use Guides

In Vivo Use Guide

7-day multiple-dose study period (50 mg tiracizine twice daily)

Route of Administration: Oral

Name

Type

Language

TIRACIZINE

Official Name

English

Tiracizine [WHO-DD]

Preferred Name

English

tiracizine [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QC01EB11

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

WHO-ATC

C01EB11

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

NCI_THESAURUS

C47793

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

Code System Code Type Description

FDA UNII

9UUO2T61K7

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

DRUG CENTRAL

2679

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

ChEMBL

CHEMBL1625260

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

MESH

C048166

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

INN

6494

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

CAS

83275-56-3

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

DRUG BANK

DB13635

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

EPA CompTox

DTXSID5048714

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

WIKIPEDIA

TIRACIZINE

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

PUBCHEM

71264

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

NCI_THESAURUS

C75137

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

EVMPD

SUB11114MIG

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

SMS_ID

100000077265

Created by admin on Wed Apr 02 08:59:16 GMT 2025 , Edited by admin on Wed Apr 02 08:59:16 GMT 2025

PRIMARY

ACTIVE MOIETY


					9UUO2T61K7