EMTRICITABINE, (+)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C8H10FN3O3S
Molecular Weight	247.247
Optical Activity	( + )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC1=NC(=O)N(C=C1F)[C@H]2CS[C@@H](CO)O2

InChI

InChIKey=XQSPYNMVSIKCOC-RITPCOANSA-N

InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.4med-pdf.com/671/6848-emtricitabine-chemistry-and-preclinical-activity.html

Emtricitabine (minus enantiomer) is a synthetic nucleoside analog of cytosine with activity against HIV-1. It’s more active and significantly less toxic than the (+) enantiomer.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Structure-activity relationships of beta-D-(2S,5R)- and alpha-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents.	1993 Sep 3	8410975

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

EMTRICITABINE, (+)-

Common Name

English

EMTRICITABINE ENANTIOMER [WHO-IP]

Common Name

English

OXATHIOLAN

Systematic Name

English

4-AMINO-5-FLUORO-1-((2S,5R)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL)PYRIMIDIN-2(1H)-ONE [WHO-IP]

Systematic Name

English

(+)-FTC

Common Name

English

2(1H)-PYRIMIDINONE, 4-AMINO-5-FLUORO-1-((2S,5R)-2-(HYDROXYMETHYL)-1,3-OXATHIOLAN-5-YL)-

Systematic Name

English

(+)-2'-DEOXY-3'-THIA-5-FLUOROCYTIDINE

Common Name

English

EMRICITABINE IMPURITY D [WHO-IP]

Common Name

English

Code System Code Type Description

FDA UNII

9PDN1V466A