SOLPECAINOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H23NO3
Molecular Weight	301.3801
Optical Activity	( + / - )
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H](COC1=CC=CC=C1)N[C@@H](CO)[C@H](O)C2=CC=CC=C2

InChI

InChIKey=DQAFKLGCFBLEOM-JCGIZDLHSA-N

InChI=1S/C18H23NO3/c1-14(13-22-16-10-6-3-7-11-16)19-17(12-20)18(21)15-8-4-2-5-9-15/h2-11,14,17-21H,12-13H2,1H3/t14-,17-,18+/m0/s1

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Description
Sources: https://adisinsight.springer.com/drugs/800003158 | https://www.tib.eu/en/search/id/elsevier%3Adoi~10.1016%252FS0031-6989%252888%252980647-7/Effect-of-EGYT-2936-a-new-antiarrhythmic-drug-on/

Solpecainol [EGIS 2936, EGYT 2936] is a sodium channel antagonist with antianginal and class I antiarrhythmic effects. It was in phase II clinical trials with Egis Pharmaceuticals for the treatment of angina pectoris and arrhythmias, but this development was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Cellular mechanisms of the action of anti-arrhythmia agents].	1978	723121

Sample Use Guides

In Vitro Use Guide

Experiments were carried out on isolated electrically driven (0.3-3 Hz) right ventricular papillary muscle and on left atrial muscle of guinea-pig. The transmembrane potentials were recorded by means of conventional microelectrode technique. The slow response APs were elicited with isoprenaline 5x10(-7)M in partially depolarized atrial and ventricular preparations. In atrium Solpecainol [EGYT-2936] only at 10(-4) M caused a significant decrease of the maximum rate of rise of AP (Vmax) and it did not influence the slow AP. The frequency-dependent effect on Vmax of 10(-5)M of EGYT-2936 was similar to that of lidocaine 10(-5)M. The drug at 10(-5)M significantly depressed OS and Vmax of slow AP.

Name

Type

Language

SOLPECAINOL

Official Name

English

SOPECAINOL

Common Name

English

solpecainol [INN]

Common Name

English

(1R*,2S*)-2-(((S*)-1-METHYL-2-PHENOXYETHYL)AMINO)-1-PHENYL-1,3-PROPANEDIOL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793