FLUOCORTOLONE PIVALATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H37FO5
Molecular Weight	460.5781
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@H](C(=O)COC(=O)C(C)(C)C)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=XZBJVIQXJHGUBE-HZMVJJPJSA-N

InChI=1S/C27H37FO5/c1-14-9-17-16-11-19(28)18-10-15(29)7-8-26(18,5)23(16)20(30)12-27(17,6)22(14)21(31)13-33-24(32)25(2,3)4/h7-8,10,14,16-17,19-20,22-23,30H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,22-,23-,26+,27+/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12650700 | https://www.ncbi.nlm.nih.gov/pubmed/3743619
Curator's Comment: description was created based on several sources, including http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1

Fluocortolone is a topical corticosteroid (class of steroid hormones formed in the adrenal gland). Is primary indicated in condition like, Ana fissure, Dermatosis haemorrhoids, proctitis. The signs and symptoms that are produced after the acute overdosage include convulsions, respiratory arrest, allergic skin reactions. Glucocorticoids, such as fluocortolone, act through nuclear hormone receptors Schaaf and Cidlowski (2002). The two members of this family are glucocorticoid receptor (GR) type I and GR type I I. Activation of these sites alters gene expression of endogenous agents that influence immune and inflammatory responses.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12650700	Binding Agent 1064

Conditions

Condition	Modality	Highest Phase	Product
Anal fissure 6 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown
Haemorrhoids 6 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown
Proctitis 4 Sources: http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1	Primary	Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis.	2003 Aug	12953943
[Bilateral uveitis intermedia. A 15-year clinical course].	2003 Dec	14704828
An integrative approach to eczema (atopic dermatitis).	2003 Jan-Feb	12597676
Orbital myositis in a patient with primary biliary cirrhosis: successful treatment with methotrexate and corticosteroids.	2003 Nov	14650113
Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories.	2010 Apr	20155493
A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves' orbitopathy.	2010 Jan	19865824
Prevention and treatment of intertrigo in large skin folds of adults: a systematic review.	2010 Jul 13	20626853
Update on the management of chronic eczema: new approaches and emerging treatment options.	2010 Jul 28	21437065
Operational post-keratopasty graft tolerance due to differential HLAMatchmaker matching.	2010 Nov 11	21152438

Patents

Sample Use Guides

In Vivo Use Guide

adult: 0.025 %; Frequency: 8 hours

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

FLUOCORTOLONE PIVALATE

Common Name

English

FLUOCORTOLONE TRIMETHYLACETATE

Common Name

English

6.ALPHA.-FLUORO-11.BETA.-HYDROXY-16.ALPHA.-METHYL-3,20-DIOXOPREGNA-1,4-DIEN-21-YL 2,2-DIMETHYLPROPANOATE

Common Name

English

FLUOCORTOLONE PIVALATE [MART.]

Common Name

English

FLUOCORTOLONE PIVALATE [EP MONOGRAPH]

Common Name

English

Fluocortolone pivalate [WHO-DD]

Common Name

English

FLUOCORTOLONE 21-PIVALATE

Common Name

English

Code System Code Type Description

CAS

29205-06-9