Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C27H37FO5 |
| Molecular Weight | 460.5781 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@@H](C)[C@H](C(=O)COC(=O)C(C)(C)C)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C
InChI
InChIKey=XZBJVIQXJHGUBE-HZMVJJPJSA-N
InChI=1S/C27H37FO5/c1-14-9-17-16-11-19(28)18-10-15(29)7-8-26(18,5)23(16)20(30)12-27(17,6)22(14)21(31)13-33-24(32)25(2,3)4/h7-8,10,14,16-17,19-20,22-23,30H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,22-,23-,26+,27+/m1/s1
| Molecular Formula | C27H37FO5 |
| Molecular Weight | 460.5781 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1
Curator's Comment: description was created based on several sources, including
http://www.druginfosys.com/Drug.aspx?DrugCode=1121&DrugName=Fluocortolone&type=1
Fluocortolone is a topical corticosteroid (class of steroid hormones formed in the adrenal gland). Is primary indicated in condition like, Ana fissure, Dermatosis haemorrhoids, proctitis. The signs and symptoms that are produced after the acute overdosage include convulsions, respiratory arrest, allergic skin reactions. Glucocorticoids, such as fluocortolone, act through nuclear hormone receptors Schaaf and Cidlowski (2002). The two members of this family are glucocorticoid receptor (GR) type I and GR type I I. Activation of these sites alters gene expression of endogenous agents that influence immune and inflammatory responses.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Contact allergies to topical corticosteroids: 10 cases of contact dermatitis. | 1991 Aug |
|
| Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial. | 2001 Apr |
|
| Systemic mycophenolate mofetil in comparison with systemic cyclosporin A in high-risk keratoplasty patients: 3 years' results of a randomized prospective clinical trial. | 2001 Jun |
|
| A case of cutaneous delayed-type allergy to oral dexamethasone and to betamethasone. | 2002 |
|
| Clocortolone pivalate cream 0.1% used concomitantly with tacrolimus ointment 0.1% in atopic dermatitis. | 2003 Aug |
|
| [Bilateral uveitis intermedia. A 15-year clinical course]. | 2003 Dec |
|
| An integrative approach to eczema (atopic dermatitis). | 2003 Jan-Feb |
|
| Childhood lichen planus with nail involvement: a case. | 2003 Jul-Sep |
|
| Orbital myositis in a patient with primary biliary cirrhosis: successful treatment with methotrexate and corticosteroids. | 2003 Nov |
|
| Syphilitic interstitial keratitis: treatment with immunosuppressive drug combination therapy. | 2004 Jul |
|
| Clinical results of anti-inflammatory therapy in Graves' ophthalmopathy and association with thyroidal autoantibodies. | 2004 Nov |
|
| Immunosuppression with cyclosporine A and mycophenolate mofetil after penetrating high-risk keratoplasty: a retrospective study. | 2005 Apr 27 |
|
| Topical FK506 as immunoprophylaxis after allogeneic penetrating normal-risk keratoplasty: a randomized clinical pilot study. | 2005 Feb |
|
| [Ranking of systemic steroids after normal-risk keratoplasty. Results of a randomized prospective study]. | 2005 May |
|
| Recurrent optic disc and retinal vasculitis in a patient with drug-induced urticarial vasculitis. | 2006 |
|
| Oral and intralesional steroid therapy in giant cell granuloma. | 2006 Jun |
|
| An open prospective pilot study on the use of rapamycin after penetrating high-risk keratoplasty. | 2006 Mar 15 |
|
| [Sudden hearing loss in a patient with a 3-mm acoustic tumor]. | 2007 |
|
| Varicella chorioretinitis. | 2007 Dec |
|
| German evidence-based guidelines for the treatment of Psoriasis vulgaris (short version). | 2007 Jun |
|
| Transrepression and transactivation potencies of inhaled glucocorticoids. | 2008 Dec |
|
| Adherence to clocortolone pivalate cream 0.1% in a pediatric population with atopic dermatitis. | 2008 May |
|
| A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples. | 2009 Apr |
|
| Stenotrophomonas maltophilia induced post-cataract-surgery endophthalmitis: Outbreak investigation and clinical courses of 26 patients. | 2009 Apr |
|
| [Retinochoroidopathy after intravitreal anti-VEGF treatment]. | 2009 Aug |
|
| Adalimumab for the treatment of fistulas in patients with Crohn's disease. | 2009 Jul |
|
| Mycophenolate mofetil (MMF) following penetrating high-risk keratoplasty: long-term results of a prospective, randomised, multicentre study. | 2009 Nov |
|
| Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. | 2010 Apr |
|
| A retrospective study on the efficacy of total absorbed orbital doses of 12, 16 and 20 Gy combined with systemic steroid treatment in patients with Graves' orbitopathy. | 2010 Jan |
|
| Prevention and treatment of intertrigo in large skin folds of adults: a systematic review. | 2010 Jul 13 |
|
| Update on the management of chronic eczema: new approaches and emerging treatment options. | 2010 Jul 28 |
|
| Operational post-keratopasty graft tolerance due to differential HLAMatchmaker matching. | 2010 Nov 11 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:10:55 UTC 2023
by
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Sat Dec 16 05:10:55 UTC 2023
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| Record UNII |
9J8AL6K50Q
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Validated (UNII)
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SUB02219MIG
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249-504-4
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DTXSID30951798
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119871
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4465
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100000091889
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