U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C18H23NO3
Molecular Weight 301.3801
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIHYDROISOCODEINE

SMILES

[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])CC[C@H]2O)=CC=C3OC

InChI

InChIKey=RBOXVHNMENFORY-KEMUOJQUSA-N
InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13+,17-,18-/m0/s1

HIDE SMILES / InChI
Dihydroisocodeine is an opioid derivative. Dihydroisocodeine is much less toxic for rabbits than codeine, and in these and other animals its convulsant action is less marked. The minimum analgesic dose for cats is considerably less than for codeine. In the 1930s it was clinically investigated for cough relief, where it has no demonstrable clinical superiority over standard codeine in the usual therapeutic dosage.

CNS Activity

Sources: CNS active in preclinical models of pain.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Patents

Patents

Sample Use Guides

In clinical trials effective oral dose was 10mg daily
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
DIHYDROISOCODEINE
MI  
Common Name English
MORPHINAN-6-OL, 4,5-EPOXY-3-METHOXY-17-METHYL-, (5.ALPHA.,6.BETA.)-
Systematic Name English
6-ISOCODEINE, 7,8-DIHYDRO-
Common Name English
6-.BETA.-HYDROCODOL
Common Name English
MORPHINAN-6.BETA.-OL, 4,5.ALPHA.-EPOXY-3-METHOXY-17-METHYL-
Systematic Name English
DIHYDROISOCODEINE [MI]
Common Name English
(-)-DIHYDROISOCODEINE
Common Name English
.BETA.-HYDROCODOL
Common Name English
DHIC
Common Name English
6.BETA.-HYDROCODOL
Common Name English
Code System Code Type Description
PUBCHEM
5492898
Created by admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
PRIMARY
WIKIPEDIA
Dihydroisocodeine
Created by admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
PRIMARY
EPA CompTox
DTXSID2048907
Created by admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
PRIMARY
CAS
795-38-0
Created by admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
PRIMARY
MERCK INDEX
m4463
Created by admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
PRIMARY Merck Index
FDA UNII
9H2016E13H
Created by admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
PRIMARY