Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C18H23NO3 |
Molecular Weight | 301.3801 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12OC3=C4C(C[C@H]5N(C)CC[C@@]14[C@@]5([H])CC[C@H]2O)=CC=C3OC
InChI
InChIKey=RBOXVHNMENFORY-KEMUOJQUSA-N
InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13+,17-,18-/m0/s1
Dihydroisocodeine is an opioid derivative. Dihydroisocodeine is much less toxic for rabbits than codeine, and in these and other animals its convulsant action is less marked. The minimum analgesic dose for cats is considerably less than for codeine. In the 1930s it was clinically investigated for cough relief, where it has no demonstrable clinical superiority over standard codeine in the usual therapeutic dosage.
CNS Activity
Originator
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Palliative | Unknown Approved UseUnknown |
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Sources: http://jpet.aspetjournals.org/content/51/1/35 |
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: http://jpet.aspetjournals.org/content/64/2/236
In clinical trials effective oral dose was 10mg daily
Route of Administration:
Oral
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5492898
Created by
admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
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Dihydroisocodeine
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admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
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DTXSID2048907
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admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
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795-38-0
Created by
admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
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m4463
Created by
admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
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9H2016E13H
Created by
admin on Sat Dec 16 09:48:17 GMT 2023 , Edited by admin on Sat Dec 16 09:48:17 GMT 2023
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SUBSTANCE RECORD