DIHYDROISOCODEINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C18H23NO3
Molecular Weight	301.3801
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C2O[C@H]3[C@H](O)CC[C@H]4[C@H]5CC(C=C1)=C2[C@@]34CCN5C

InChI

InChIKey=RBOXVHNMENFORY-KEMUOJQUSA-N

InChI=1S/C18H23NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-13,17,20H,4-5,7-9H2,1-2H3/t11-,12+,13+,17-,18-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C18H23NO3
Molecular Weight	301.3801
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://jpet.aspetjournals.org/content/64/2/236 | http://jpet.aspetjournals.org/content/51/1/35

Dihydroisocodeine is an opioid derivative. Dihydroisocodeine is much less toxic for rabbits than codeine, and in these and other animals its convulsant action is less marked. The minimum analgesic dose for cats is considerably less than for codeine. In the 1930s it was clinically investigated for cough relief, where it has no demonstrable clinical superiority over standard codeine in the usual therapeutic dosage.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pulmonary tuberculosis 17 Sources: http://jpet.aspetjournals.org/content/64/2/236	Palliative		Not Provided 511	Unknown Approved Use Unknown
Pain 619 Sources: http://jpet.aspetjournals.org/content/51/1/35	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Enantioselective synthesis of (-)-dihydrocodeinone: a short formal synthesis of (-)-morphine.	2006-01-20	16408951

Patents

Sample Use Guides

In Vivo Use Guide

In clinical trials effective oral dose was 10mg daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:50:46 GMT 2025` Edited by `admin` on `Mon Mar 31 22:50:46 GMT 2025`
Record UNII	9H2016E13H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIHYDROISOCODEINE

Common Name

English

(-)-DIHYDROISOCODEINE

Preferred Name

English

MORPHINAN-6-OL, 4,5-EPOXY-3-METHOXY-17-METHYL-, (5.ALPHA.,6.BETA.)-

Systematic Name

English

6-ISOCODEINE, 7,8-DIHYDRO-

Common Name

English

6-.BETA.-HYDROCODOL

Common Name

English

MORPHINAN-6.BETA.-OL, 4,5.ALPHA.-EPOXY-3-METHOXY-17-METHYL-

Systematic Name

English

DIHYDROISOCODEINE [MI]

Common Name

English

.BETA.-HYDROCODOL

Common Name

English

DHIC

Common Name

English

6.BETA.-HYDROCODOL

Common Name

English

Code System Code Type Description

PUBCHEM

5492898