MILENPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23ClFN3O2
Molecular Weight	415.888
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C(=O)C2CCN(CCCN3C(=O)NC4=C3C=CC(Cl)=C4)CC2

InChI

InChIKey=DBESQBZOXMCXPV-UHFFFAOYSA-N

InChI=1S/C22H23ClFN3O2/c23-17-4-7-20-19(14-17)25-22(29)27(20)11-1-10-26-12-8-16(9-13-26)21(28)15-2-5-18(24)6-3-15/h2-7,14,16H,1,8-13H2,(H,25,29)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6146246 | https://www.ncbi.nlm.nih.gov/pubmed/3900796 | https://www.ncbi.nlm.nih.gov/pubmed/3090584

Milenperone, a dopamine receptor antagonist was studied as an antipsychotic drug. It participated in clinical trials in the management of aggressive behavior in alcoholics and epileptics. Besides, the effect of milenperone was studied for the aggressive behavior of oligophrenic patients. However, information about the further development of the drug is not available.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D2 receptor 297 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2863777 \| https://www.ncbi.nlm.nih.gov/pubmed/9342550	Antagonist 2778

PubMed

Title	Date	PubMed
Milenperone. A selective drug for the control of behavioral disorders in epileptic and alcoholic patients.	1984 Mar-Apr	6146246
The effect of milenperone on the aggressive behavior of oligophrenic patients. A double-blind placebo-controlled study.	1985	3900796
The effect of milenperone on the aggressive behavior of psychogeriatric patients. A double-blind placebo-controlled study.	1985	2863777
Bromocriptine and apomorphine stimulation of cortisol secretion in conscious dogs; evidence for a stimulatory site located outside the blood brain barrier.	1986	3090584

Sample Use Guides

In Vivo Use Guide

was administered in a dose of 2 X 10 mg daily for 6 weeks

Route of Administration: Oral

Name

Type

Language

MILENPERONE

Official Name

English

2H-BENZIMIDAZOL-2-ONE, 5-CHLORO-1-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPYL)-1,3-DIHYDRO-

Systematic Name

English

R-34009

Code

English

5-CHLORO-1-(3-(4-(P-FLUOROBENZOYL)PIPERIDINO)PROPYL)-2-BENZIMIDAZOLINONE

Common Name

English

MILENPERONE [USAN]

Common Name

English

R 34,009

Code

English

MILENPERONE [MART.]

Common Name

English

milenperone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197