MILENPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23ClFN3O2
Molecular Weight	415.888
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C(=O)C2CCN(CCCN3C(=O)NC4=C3C=CC(Cl)=C4)CC2

InChI

InChIKey=DBESQBZOXMCXPV-UHFFFAOYSA-N

InChI=1S/C22H23ClFN3O2/c23-17-4-7-20-19(14-17)25-22(29)27(20)11-1-10-26-12-8-16(9-13-26)21(28)15-2-5-18(24)6-3-15/h2-7,14,16H,1,8-13H2,(H,25,29)

HIDE SMILES / InChI

Molecular Formula	C22H23ClFN3O2
Molecular Weight	415.888
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6146246 | https://www.ncbi.nlm.nih.gov/pubmed/3900796 | https://www.ncbi.nlm.nih.gov/pubmed/3090584

Milenperone, a dopamine receptor antagonist was studied as an antipsychotic drug. It participated in clinical trials in the management of aggressive behavior in alcoholics and epileptics. Besides, the effect of milenperone was studied for the aggressive behavior of oligophrenic patients. However, information about the further development of the drug is not available.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D2 receptor 311 Target ID: CHEMBL217 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2863777 \| https://www.ncbi.nlm.nih.gov/pubmed/9342550	Antagonist 2849

PubMed

Title	Date	PubMed
Bromocriptine and apomorphine stimulation of cortisol secretion in conscious dogs; evidence for a stimulatory site located outside the blood brain barrier.	1986	3090584
The effect of milenperone on the aggressive behavior of oligophrenic patients. A double-blind placebo-controlled study.	1985	3900796
The effect of milenperone on the aggressive behavior of psychogeriatric patients. A double-blind placebo-controlled study.	1985	2863777
Milenperone. A selective drug for the control of behavioral disorders in epileptic and alcoholic patients.	1984-03-01	6146246

Sample Use Guides

In Vivo Use Guide

was administered in a dose of 2 X 10 mg daily for 6 weeks

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:26:04 GMT 2025` Edited by `admin` on `Mon Mar 31 18:26:04 GMT 2025`
Record UNII	9GC5JKP4BD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MILENPERONE

Official Name

English

R 34,009

Preferred Name

English

2H-BENZIMIDAZOL-2-ONE, 5-CHLORO-1-(3-(4-(4-FLUOROBENZOYL)-1-PIPERIDINYL)PROPYL)-1,3-DIHYDRO-

Systematic Name

English

R-34009

Code

English

5-CHLORO-1-(3-(4-(P-FLUOROBENZOYL)PIPERIDINO)PROPYL)-2-BENZIMIDAZOLINONE

Common Name

English

MILENPERONE [USAN]

Common Name

English

MILENPERONE [MART.]

Common Name

English

milenperone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197