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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3Cl3O4P.Na
Molecular Weight 251.365
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRICLOFOS SODIUM

SMILES

[Na+].OP([O-])(=O)OCC(Cl)(Cl)Cl

InChI

InChIKey=WFKJEZKHPGDCRK-UHFFFAOYSA-M
InChI=1S/C2H4Cl3O4P.Na/c3-2(4,5)1-9-10(6,7)8;/h1H2,(H2,6,7,8);/q;+1/p-1

HIDE SMILES / InChI

Description

Triclofos is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Nausea, vertigo, labyrinthine disorders. It is also used sedate people suffering from anxiety or tension before medical investigations. Triclofos is converted to Trichloroethanol in the body .This act on brain and produces sleep. Trichloroethanol decreases time taken to fall asleep and lengthen the sleep. Triclofos is most commonly used agent for sedation in neonates as well as in older infants and children in Japan.

CNS Activity

Originator

Approval Year

1972
178
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
TRICLOS

Approved Use

Triclofos is used to treat sleeping problems (insomnia) in people. It is also used sedate people suffering from anxiety or tension before medical investigations.
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
8 h
REVIEW
https://www.sciencedirect.com/science/article/pii/B9780080552323627977
1 g single, oral
dose: 1 g
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLOFOS plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
65%
REVIEW
https://www.sciencedirect.com/science/article/pii/B9780080552323627977
1 g single, oral
dose: 1 g
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLOFOS plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
100 mg/kg single, oral
Highest studied dose
Dose: 100 mg/kg
Route: oral
Route: single
Dose: 100 mg/kg
Sources:
https://pubmed.ncbi.nlm.nih.gov/15238906
unhealthy, children
Health Status: unhealthy
Age Group: children
Sources:
https://pubmed.ncbi.nlm.nih.gov/15238906
Sources:
https://pubmed.ncbi.nlm.nih.gov/15238906
Sourcing

Sourcing

Vendor/AggregatorIDURL
001 Chemical
DY447186
https://www.001chemical.com/chem/306-52-5
AHH Chemical co.,ltd
MR-1008646
http://www.ahhchemical.com/product/MR-1008646.html
Ambinter
Amb22733929
http://www.ambinter.com/reference/22733929
Boerchem
BC681093
http://www.boerchem.com/?product_39976.html
ChemMol
49416170
http://www.chemmol.com/chemmol/49416170.html
Molcore
MC447186
https://www.molcore.com/product/306-52-5
Smolecule
S576546
https://www.smolecule.com/products/s576546
THE BioTek
bt-308557
https://www.thebiotek.com/product/others/bt-308557
Yuhao Chemical
XJ0609
http://www.chemyuhao.com/306-52-5.html
iChemical
EBD49808
http://www.ichemical.com/chemicals/cas-306-52-5
PubMed

PubMed

TitleDatePubMed
Iatrogenic encephalopathy.
1970 May
Comparison of resistance measured by the interrupter technique and by passive mechanics in sedated infants.
2001 Aug
Neonatal outcome following maternal opiate use in late pregnancy.
2001 Sep
A comparative evaluation of oral midazolam with other sedatives as premedication in pediatric dentistry.
2002 Winter
A pediatric sedation/anesthesia program with dedicated care by anesthesiologists and nurses for procedures outside the operating room.
2004 Jul
An analysis of oxygen consumption and oxygen delivery in euthermic infants after cardiopulmonary bypass with modified ultrafiltration.
2004 Oct
Non-epileptic pedaling-like movement induced by triclofos.
2004 Oct
[Severe airway obstruction relieved by sedation using sevoflurane in a pediatric patient with tracheobronchomalacia].
2005 Feb
Efficacy and adverse effects of rectal thiamylal with oral triclofos for children undergoing magnetic resonance imaging.
2006 Apr
Transient administration of triclofos sodium is helpful in minimizing anticonvulsants under polypharmacy.
2006 Dec
A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry.
2006 Feb 10
Comparison of solvent mixtures for pressurized solvent extraction of soil fatty acid biomarkers.
2008 Oct 19
Proteomic analysis of regenerating mouse liver following 50% partial hepatectomy.
2009 Dec 29
Modeling hydroxyl radical distribution and trialkyl phosphates oxidation in UV-H2O2 photoreactors using computational fluid dynamics.
2010 Aug 15
Procedural sedation analgesia.
2010 Jan
Patents

Patents

EP0001965
2
EP0005549
2
EP1273301A2
4

Sample Use Guides

In Vivo Use Guide
The usual adult dose as a hypnotic is 1 to 2 g orally at night. A suggested hypnotic dose for children 1 month to 1 year of age is 25 to 30 mg/kg; children aged 1 to 5 years may be given single doses of 250 to 500 mg, and children aged 6 to 12 years may be given single doses of 0.5 to 1 g.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
TRICLOFOS SODIUM
MART.   ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
TRICLOS
Brand Name English
ETHANOL, 2,2,2-TRICHLORO-, DIHYDROGEN PHOSPHATE MONOSODIUM SALT
Common Name English
TRICLOFOS SODIUM [MART.]
Common Name English
2,2,2-Trichloroethanol dihydrogen phosphate monosodium salt
Common Name English
TRICLOFOS MONOSODIUM SALT
MI  
Common Name English
Triclofos sodium [WHO-DD]
Common Name English
SCH-10159
Code English
SCH 10159
Code English
SODIUM TRICLOFOS
Systematic Name English
TRICLOFOS SODIUM [USAN]
Common Name English
TRICLOFOS MONOSODIUM SALT [MI]
Common Name English
TRICLOFOS SODIUM [JAN]
Common Name English
TRICLOFOS SODIUM [ORANGE BOOK]
Common Name English
TRICLORYL
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C29756
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
Code System Code Type Description
EVMPD
SUB15606MIG
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
DRUG BANK
DBSALT001424
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
PUBCHEM
23677832
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PRIMARY
MERCK INDEX
m11090
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
230-652-3
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201317
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
EPA CompTox
DTXSID60993262
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PRIMARY
CAS
7246-20-0
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
FDA UNII
9F90KA5Q8U
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
RXCUI
104696
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY RxNorm
SMS_ID
100000077273
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
NCI_THESAURUS
C66630
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of TRICLOFOS
SUBSTANCE RECORD
Structure of TRICLOFOS SODIUM
NIH
NCATS
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