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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3Cl3O4P.Na
Molecular Weight 251.365
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRICLOFOS SODIUM

SMILES

[Na+].OP([O-])(=O)OCC(Cl)(Cl)Cl

InChI

InChIKey=WFKJEZKHPGDCRK-UHFFFAOYSA-M
InChI=1S/C2H4Cl3O4P.Na/c3-2(4,5)1-9-10(6,7)8;/h1H2,(H2,6,7,8);/q;+1/p-1

HIDE SMILES / InChI

Description

Triclofos is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Nausea, vertigo, labyrinthine disorders. It is also used sedate people suffering from anxiety or tension before medical investigations. Triclofos is converted to Trichloroethanol in the body .This act on brain and produces sleep. Trichloroethanol decreases time taken to fall asleep and lengthen the sleep. Triclofos is most commonly used agent for sedation in neonates as well as in older infants and children in Japan.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TRICLOS

T1/2

ValueDoseCo-administeredAnalytePopulation
8 h
1 g single, oral
TRICLOFOS plasma
Homo sapiens

Funbound

ValueDoseCo-administeredAnalytePopulation
65%
1 g single, oral
TRICLOFOS plasma
Homo sapiens

Doses

PubMed

Sample Use Guides

In Vivo Use Guide
The usual adult dose as a hypnotic is 1 to 2 g orally at night. A suggested hypnotic dose for children 1 month to 1 year of age is 25 to 30 mg/kg; children aged 1 to 5 years may be given single doses of 250 to 500 mg, and children aged 6 to 12 years may be given single doses of 0.5 to 1 g.
Route of Administration: Oral
In Vitro Use Guide
Unknown