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Details

Stereochemistry ACHIRAL
Molecular Formula C2H3Cl3O4P.Na
Molecular Weight 251.365
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRICLOFOS SODIUM

SMILES

[Na+].OP([O-])(=O)OCC(Cl)(Cl)Cl

InChI

InChIKey=WFKJEZKHPGDCRK-UHFFFAOYSA-M
InChI=1S/C2H4Cl3O4P.Na/c3-2(4,5)1-9-10(6,7)8;/h1H2,(H2,6,7,8);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C2H3Cl3O4P
Molecular Weight 228.376
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Triclofos is primarily indicated in conditions like Insomnia, and can also be given in adjunctive therapy as an alternative drug of choice in Nausea, vertigo, labyrinthine disorders. It is also used sedate people suffering from anxiety or tension before medical investigations. Triclofos is converted to Trichloroethanol in the body .This act on brain and produces sleep. Trichloroethanol decreases time taken to fall asleep and lengthen the sleep. Triclofos is most commonly used agent for sedation in neonates as well as in older infants and children in Japan.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TRICLOS

Approved Use

Triclofos is used to treat sleeping problems (insomnia) in people. It is also used sedate people suffering from anxiety or tension before medical investigations.
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
8 h
1 g single, oral
dose: 1 g
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLOFOS plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
65%
1 g single, oral
dose: 1 g
route of administration: Oral
experiment type: SINGLE
co-administered:
TRICLOFOS plasma
Homo sapiens
population: UNKNOWN
age: ADULT
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
100 mg/kg single, oral
Highest studied dose
Dose: 100 mg/kg
Route: oral
Route: single
Dose: 100 mg/kg
Sources:
unhealthy, children
Health Status: unhealthy
Age Group: children
Sources:
PubMed

PubMed

TitleDatePubMed
Iatrogenic encephalopathy.
1970 May
A pediatric sedation/anesthesia program with dedicated care by anesthesiologists and nurses for procedures outside the operating room.
2004 Jul
Non-epileptic pedaling-like movement induced by triclofos.
2004 Oct
[Severe airway obstruction relieved by sedation using sevoflurane in a pediatric patient with tracheobronchomalacia].
2005 Feb
Modeling hydroxyl radical distribution and trialkyl phosphates oxidation in UV-H2O2 photoreactors using computational fluid dynamics.
2010 Aug 15
Patents

Sample Use Guides

The usual adult dose as a hypnotic is 1 to 2 g orally at night. A suggested hypnotic dose for children 1 month to 1 year of age is 25 to 30 mg/kg; children aged 1 to 5 years may be given single doses of 250 to 500 mg, and children aged 6 to 12 years may be given single doses of 0.5 to 1 g.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:35:50 GMT 2023
Edited
by admin
on Fri Dec 15 15:35:50 GMT 2023
Record UNII
9F90KA5Q8U
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRICLOFOS SODIUM
MART.   ORANGE BOOK   USAN   WHO-DD  
USAN  
Official Name English
TRICLOS
Brand Name English
ETHANOL, 2,2,2-TRICHLORO-, DIHYDROGEN PHOSPHATE MONOSODIUM SALT
Common Name English
TRICLOFOS SODIUM [MART.]
Common Name English
2,2,2-Trichloroethanol dihydrogen phosphate monosodium salt
Common Name English
TRICLOFOS MONOSODIUM SALT
MI  
Common Name English
Triclofos sodium [WHO-DD]
Common Name English
SCH-10159
Code English
SCH 10159
Code English
SODIUM TRICLOFOS
Systematic Name English
TRICLOFOS SODIUM [USAN]
Common Name English
TRICLOFOS MONOSODIUM SALT [MI]
Common Name English
TRICLOFOS SODIUM [JAN]
Common Name English
TRICLOFOS SODIUM [ORANGE BOOK]
Common Name English
TRICLORYL
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C29756
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
Code System Code Type Description
EVMPD
SUB15606MIG
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
DRUG BANK
DBSALT001424
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
PUBCHEM
23677832
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
MERCK INDEX
m11090
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
230-652-3
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
ChEMBL
CHEMBL1201317
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
EPA CompTox
DTXSID60993262
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
CAS
7246-20-0
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
FDA UNII
9F90KA5Q8U
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
RXCUI
104696
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY RxNorm
SMS_ID
100000077273
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
NCI_THESAURUS
C66630
Created by admin on Fri Dec 15 15:35:50 GMT 2023 , Edited by admin on Fri Dec 15 15:35:50 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY