Pridinol

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C20H25NO
Molecular Weight	295.4186
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CCN1CCCCC1)(C2=CC=CC=C2)C3=CC=CC=C3

InChI

InChIKey=RQXCLMGKHJWMOA-UHFFFAOYSA-N

InChI=1S/C20H25NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1-2,4-7,10-13,22H,3,8-9,14-17H2

HIDE SMILES / InChI

Description
Sources: http://www.mims.com/india/drug/info/pridinol?type=full&mtype=generic | https://www.ncbi.nlm.nih.gov/pubmed/12935797 | http://mmpharm1.tradekorea.com/product/detail/P260632/Skeletal-Muscle-Relaxants.html?minisiteprodgroupno=29432

Pridinol mesilate is a centrally acting muscle relaxant that is used in the symptomatic treatment of muscle spasm. It is also used as the hydrochloride salt for its antimuscarinic activity in the management of parkinsonism.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 162 Target ID: CHEMBL2094109 Sources: http://www.genome.jp/dbget-bin/www_bget?D08418 \| https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+2684 \| https://www.ncbi.nlm.nih.gov/pubmed/8102927	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Muscle spasm 41 Sources: http://mmpharm1.tradekorea.com/product/detail/P260632/Skeletal-Muscle-Relaxants.html?minisiteprodgroupno=29432 https://www.ncbi.nlm.nih.gov/pubmed/12935797	Primary		Approved 8583	Pridinol Approved Use Muscle spasms

C_max

Value	Dose	Co-administered	Analyte	Population
31.04 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/33835016/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:		PRIDINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
197.11 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/33835016/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:		PRIDINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
18 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/33835016/	3 mg single, oral dose: 3 mg route of administration: Oral experiment type: SINGLE co-administered:		PRIDINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
68.67% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/15490448/			PRIDINOL serum	Homo sapiens

Doses

Dose	Population	Adverse events
3 mg single, oral Recommended Dose: 3 mg Route: oral Route: single Dose: 3 mg Sources: https://pubmed.ncbi.nlm.nih.gov/33835016/	healthy, ADULT Health Status: healthy Age Group: ADULT Sex: M+F Food Status: FASTED Sources: https://pubmed.ncbi.nlm.nih.gov/33835016/	Sources: https://pubmed.ncbi.nlm.nih.gov/33835016/

PubMed

Title	Date	PubMed
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011-07-14	21599003
Development and validation of a dissolution test for meloxicam and pridinol mesylate from combined tablet formulation.	2010-03	20838523
Development and validation of an HPLC method for the determination of process-related impurities in pridinol mesylate, employing experimental designs.	2009-11-10	19854345
Validated stability-indicating HPLC method for the determination of pridinol mesylate. Kinetics study of its degradation in acid medium.	2008-12-01	18922659
Method development and validation for the simultaneous determination of meloxicam and pridinol mesylate using RP-HPLC and its application in drug formulations.	2008-01-22	17961953
Suicide by multidrug ingestion: hypothesis on the role played by the self-administration of activated charcoal.	2007-03	17325466
Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection.	2004-10	15490448
Effect of muscle relaxants on experimental jaw-muscle pain and jaw-stretch reflexes: a double-blind and placebo-controlled trial.	2003	12935797

Patents

Sample Use Guides

In Vivo Use Guide

Oral Muscle spasms Adult: As mesilate: Usual initial: 2-8 mg tid; Maintenance: 4-8 mg daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

C-238

Preferred Name

English

Pridinol

Official Name

English

1,1-Diphenyl-3-(1-piperidyl)-1-propanol

Systematic Name

English

Pridinol [HSDB]

Common Name

English

1-Piperidinepropanol, ?,?-diphenyl-

Systematic Name

English

Pridinol [WHO-DD]

Common Name

English

3-(N-Piperidyl)-1,1-diphenyl-1-propanol

Systematic Name

English

NSC-23016

Code

English

Pridinol [MI]

Common Name

English

Pridinol [INN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QM03BX03